Document Detail


Pemphigus and associated environmental factors: a case-control study.
MedLine Citation:
PMID:  17355277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent reports have revealed the relatively high incidence of pemphigus in Iran. Occupational exposure and personal habits have been suggested to play a role in the aetiopathogenesis of this life-threatening disease. AIM: In order to analyse the association of environmental factors with pemphigus, we conducted a case-control study to evaluate the possible role of smoking, pesticide exposure and hormonal factors in Iran. METHODS: This study was conducted in Iran using a structured questionnaire. Questions included information on patients' smoking habits, occupational exposure to pesticides, use of oral contraception (OC) and number of pregnancies. RESULTS: We enrolled 210 patients with pemphigus and 205 control subjects. Fewer of patients with pemphigus (17.1%) reported a current or past history of smoking, which was statistically different from the control group (27.3% smokers). The duration of smoking and the number of cigarettes smoked daily was also significantly lower in patients. Although OC use was significantly higher in women with pemphigus, the mean number of pregnancies was not different between the two groups. Occupational exposure to pesticides was significantly higher in patients with pemphigus (14.8%) than in controls (5.4%); patients with pemphigus were exposed to pesticides three times more often than were healthy subjects. CONCLUSION: As a positive history of smoking was lower in patients with pemphigus compared with healthy subjects, it seems that smoking is a protective factor in pemphigus. This should encourage further investigations, searching for novel therapies. If pesticides and OC are confirmed as triggering factors, their cessation might reduce the need for pharmacological therapy.
Authors:
M Valikhani; S Kavusi; C Chams-Davatchi; M Daneshpazhooh; M Barzegari; M Ghiasi; R Abedini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-13
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  32     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
Affiliation:
Pemphigus Researh Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Contraceptives, Oral, Hormonal / adverse effects*
Female
Humans
Iran / epidemiology
Male
Middle Aged
Occupational Exposure / adverse effects*
Pemphigus / chemically induced*,  epidemiology
Pesticides / toxicity*
Pregnancy
Questionnaires
Risk Factors
Smoking / adverse effects*
Chemical
Reg. No./Substance:
0/Contraceptives, Oral, Hormonal; 0/Pesticides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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