Document Detail

Pemphigus vulgaris: bilateral plica semilunaris involvement.
MedLine Citation:
PMID:  21045669     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: : To present a case of pemphigus vulgaris, involving the conjunctiva, specifically the plica semilunaris, in both eyes of a 33-year-old woman.
METHODS: : Ocular evaluation showed bilateral plica semilunaris vegetations extending for 3 mm linearly. Sequential excisional biopsies of both affected plica were performed and sent for pathological examination and immunofluorescent staining.
RESULTS: : After each excisional biopsy, the patient's ocular symptoms resolved. Excisional biopsies showed suprabasilar clefting within the epithelium; lymphoplasmacytic infiltration and immunopathology showed intraepithelial intercellular and basement membrane zone staining with immunoglobulin G consistent with pemphigus vulgaris. At 1-year follow-up, the patient continues to be asymptomatic with no signs of recurrence.
CONCLUSIONS: : Excisional biopsy, in a very symptomatic patient with pemphigus vulgaris with conjunctival vegetations, may hasten his or her recovery.
Jay M Fiore; Henry D Perry; Eric D Donnenfeld; Samuel A Berger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cornea     Volume:  30     ISSN:  1536-4798     ISO Abbreviation:  Cornea     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-9     Citation Subset:  IM    
From the *Ophthalmic Consultants of Long Island, Rockville Centre, NY; and †Liebergall & Paskowski Eye Associates.
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