| Pemphigoid gestationis. | |
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MedLine Citation:
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PMID: 22137226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pemphigoid gestationis is a rare autoimmune subepidermal bullous dermatosis that occurs during pregnancy and postpartum. Diagnosis is made on the basis of the presence of a subepidermal vesicle on routine histologic examination and of linear deposition of complement along the basement membrane zone of perilesional skin. The disorder is accompanied by severe pruritus and polymorphous bullous skin lesions. Clinical diagnosis is confirmed by histology and positive cutaneous immunofluorescence and immunoelectron microscopy tests (linear deposition of C3, with or without immunoglobulin G, along the basement membrane zone, within the lamina lucida, and localized to the proximal part of anchoring filaments of the epidermal fragment of salt-split skin). Enzyme-linked immunosorbent assay for pemphigoid gestationis antibody (BP180) is commercially available. If local treatment fails, systemic corticosteroid therapy should be administered. Oral corticosteroids are the therapeutic mainstay in pregnancy and postpartum. The prognosis is good for mother and child, except that there is a risk of preterm delivery and of moderate fetal growth restriction. Recurrence is possible during subsequent pregnancies. There is no significant maternal morbidity or mortality. |
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Authors:
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Jasna Lipozenčić; Suzana Ljubojevic; Zrinka Bukvić-Mokos |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinics in dermatology Volume: 30 ISSN: 1879-1131 ISO Abbreviation: Clin. Dermatol. Publication Date: 2012 Jan-Feb |
Date Detail:
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Created Date: 2011-12-05 Completed Date: 2012-03-30 Revised Date: 2012-05-24 |
Medline Journal Info:
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Nlm Unique ID: 8406412 Medline TA: Clin Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 51-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Croatia. jasna.lipozencic@zg.htnet.hr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use* Anti-Bacterial Agents / therapeutic use Autoantigens / blood Basement Membrane / immunology Dermatologic Agents / therapeutic use* Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin G / blood Non-Fibrillar Collagens / blood Pemphigoid Gestationis / blood, diagnosis*, drug therapy* Pregnancy Pregnancy Outcome Prenatal Care / methods Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Bacterial Agents; 0/Autoantigens; 0/Dermatologic Agents; 0/Immunoglobulin G; 0/Non-Fibrillar Collagens; 0/collagen type XVII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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