Document Detail


Pemetrexed plus Carboplatin or Cisplatin as Neoadjuvant Treatment of Operable Malignant Pleural Mesothelioma (MPM).
MedLine Citation:
PMID:  23225442     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PATIENTS AND METHODS: Patients with operable MPM received three cycles of AC or AP followed by surgery and radiotherapy.
RESULTS: Since 2005, 51 patients have been treated with AC (27) and AP (24). We observed higher incidence of grade 3 anaemia, cumulative grade 2-3 asthenia and worsening of performance status in the AP group. Response to AC and AP were; complete: 4% vs. 0%, partial: 18% vs. 17%, stable disease: 74% vs. 79%, progressive disease: 4%; the resection rate was 81% vs. 79%.
CONCLUSION: AC and AP are active and feasible neoadjuvant regimens. Progression-free survival, response, disease control and resection rate were similar in the two treatment groups. The lower tolerability to AP treatment could impair the clinical condition of patients undergoing surgery.
Authors:
Giulia Pasello; Giuseppe Marulli; Valentina Polo; Cristiano Breda; Laura Bonanno; Lucio Loreggian; Federico Rea; Adolfo Favaretto
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5393-9     Citation Subset:  IM    
Affiliation:
Via Gattamelata 64, 35128, Padua, Italy. giulia.pasello@ioveneto.it.
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