Document Detail


Pemetrexed in the treatment of malignant mesothelioma: results from an expanded access program in Germany.
MedLine Citation:
PMID:  19818589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An international expanded access program was initiated to provide access to treatment with pemetrexed prior registration and reimbursement for malignant mesothelioma (MM). Chemonaïve and pretreated patients with inoperable MM of the pleura or peritoneum were eligible. This report describes the results obtained in German centers. Investigators could choose between three treatments: Pemetrexed 500 mg/m(2) alone (P) or in combination with cisplatin 75 mg/m(2) (PC) or carboplatin AUC 5 (PCb). From November 2002 to June 2004, a total of 567 patients (554 with pleural MM; 41% pretreated) were included. Of 548 evaluable patients with pleural MM, 191 received P, 137 PC and 220 PCb. Patients in the P group were more often pretreated (70%) and had worse performance status compared with the other groups. In the P, PC, and PCb groups overall response rate (ORR) was 16%, 24% and 18%, median time to progression (TTP) was 5.5, 8.2, and 6.9 months, and median overall survival (OS) was 8.7, 11.3 and 9.7 months respectively. Efficacy outcomes were better for chemonaïve than for pretreated patients, and P was less hematotoxic than PC or PCb. Treatment of pleural MM with pemetrexed alone or in combination with platinum was safe and active as first and second-line therapy.
Authors:
Martin Reck; Rolf A Stahel; Joachim von Pawel; Meinolf Karthaus; Soenke Korfee; Monika Serke; Wolfgang H-W Schuette; Corinna Eschbach; Thomas H Fink; Monika I Leschinger; Christian Manegold
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Publication Detail:
Type:  Journal Article     Date:  2009-10-08
Journal Detail:
Title:  Respiratory medicine     Volume:  104     ISSN:  1532-3064     ISO Abbreviation:  Respir Med     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-09-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pneumology and Thoracic Surgery, Hospital Grosshansdorf, Woehrendamm 80, D-22927 Grosshansdorf, Germany. dr.martin.reck@web.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antineoplastic Agents / therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Carboplatin / administration & dosage
Cisplatin / administration & dosage
Disease Progression
Drug Administration Schedule
Female
Germany
Glutamates / administration & dosage,  therapeutic use*
Guanine / administration & dosage,  analogs & derivatives*,  therapeutic use
Humans
Male
Mesothelioma / drug therapy*,  mortality
Middle Aged
Neoplasm Staging
Peritoneal Neoplasms / drug therapy*,  mortality
Pleural Neoplasms / drug therapy*,  mortality
Prognosis
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Glutamates; 137281-23-3/pemetrexed; 15663-27-1/Cisplatin; 41575-94-4/Carboplatin; 73-40-5/Guanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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