Document Detail

Pelvic vascular prospects for uterine transplantation.
MedLine Citation:
PMID:  16967683     Owner:  NLM     Status:  MEDLINE    
While developing the technique of abdominal radical trachelectomy for conservative cervical cancer management, the vascular supply of the uterus was thoroughly examined. This was a prelude to study the possibility of uterine transplantation where initial concerns were about how uterine artery anastomosis might be achieved and the subsequent function of these vessels in pregnancy. In experiment 1, the uterine arteries in two sows were divided and reanastomosed. At 6 weeks, all sows including control were inseminated. After weaning 3 months after delivery, the sows were killed, and postmortem studies were undertaken. Successful reanastomoses of the uterine arteries were accomplished in both study sows. After insemination, pregnancy proceeded uneventfully, and both sows farrowed normally with average litter sizes. Histopathology of the uterine arteries revealed minimal intimal fibrosis across all anastomotic sites. Uterine artery anastomosis in the porcine model is feasible with subsequent normal vascular function in pregnancy of the anastomosed vessels.
Krishen Sieunarine; Deborah C M Boyle; David J Corless; David E Noakes; Laszlo Ungar; Celia E Marr; Ian Lindsay; Giuseppe Del Priore; J Richard Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International surgery     Volume:  91     ISSN:  0020-8868     ISO Abbreviation:  Int Surg     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-09-13     Completed Date:  2006-12-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0043524     Medline TA:  Int Surg     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  IM    
Imperial College School of Medicine and Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, London, United Kingdom.
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MeSH Terms
Anastomosis, Surgical
Arteries / surgery*
Blood Flow Velocity
Ovary / blood supply*
Uterine Cervical Neoplasms / surgery
Uterus / blood supply*,  surgery*
Veins / surgery

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