Document Detail

Pelvic organ prolapse and connective tissue abnormalities in Korean women.
MedLine Citation:
PMID:  11933689     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the relationship between pelvic organ prolapse in Korean women and joint hypermobility, which suggests a metabolic collagen fiber abnormality. STUDY DESIGN: Between March 1998 and March 2000, we investigated 55 patients with prolapse. The prevalence of joint hypermobility, by measuring finger extension angle, and the proportion of patients with joint hypermobility were measured in patients with pelvic organ prolapse and benign gynecologic patients (control group). RESULTS: In middle-aged women (40-59 years), the average finger extension angles were higher in the POP group than in the control group (50.04 +/- 9.70 degrees vs. 39.50 +/- 12.19 degrees, respectively; P < .05), but in older women there was no significant difference between the two groups (42.84 +/- 13.05 degrees vs. 43.00 +/- 13.34 degrees, respectively; P > .05). CONCLUSION: The prevalence of joint hypermobility was higher in the POP group and with advanced POP stage (III, IV) than in the control group and early POP stage (I, II). Our results suggest that intrinsic connective tissue abnormality is related to the development of pelvic organ prolapse. Further study involving more patients with pelvic organ prolapse is warranted, and molecular studies to determine the genetic basis of pelvic organ prolapse are also required to further elucidate this abnormality.
Sang Wook Bai; Byung Hoon Choe; Jeong Yeon Kim; Ki Hyun Park
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  47     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-05     Completed Date:  2002-09-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  231-4     Citation Subset:  IM    
Division of Urogynecology, Department of Obstetrics and Gynecology, Yonsei University, College of Medicine, Seoul, Korea.
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MeSH Terms
Connective Tissue Diseases / complications*,  ethnology
Joint Instability / complications*,  ethnology
Korea / ethnology
Middle Aged
Pelvis / pathology
Risk Factors
Uterine Prolapse / ethnology,  etiology*,  physiopathology

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