Document Detail


Pelvic floor muscles and the external urethral sphincter have different responses to applied bladder pressure during continence.
MedLine Citation:
PMID:  20206969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine the functional innervation of the pelvic floor muscles (PFM) and whether there is PFM activity during an external pressure increase to the bladder in female rats.
METHODS: Thirty-one female adult virgin Sprague-Dawley rats received an external increase in bladder pressure until urinary leakage was noted while bladder pressure was recorded (leak point pressure [LPP]) under urethane anesthesia. Six of the rats underwent repeat LPP testing after bilateral transection of the levator ani nerve. Another 6 rats underwent repeat LPP testing after bilateral transection of the pudendal nerve. Simultaneous recordings of PFM (pubo- and iliococcygeus muscles), electromyogram (EMG), and external urethral sphincter (EUS) EMG were recorded during cystometry and LPP testing.
RESULTS: Thirteen rats (42%) showed tonic PFM EMG activity during filling cystometry. Eighteen rats (58%) showed no tonic PFM EMG activity at baseline, but PFM EMG could be activated by pinching the perineal skin. This activity could be maintained unless voiding occurred. The external increase in bladder pressure caused significantly increased EUS EMG activity as demonstrated by increased amplitude and frequency. However, there was no such response in PFM EMG. LPP was not significantly different after levator ani nerve transection, but was significantly decreased after pudendal nerve transection.
CONCLUSIONS: PFM activity was not increased during external pressure increases to the bladder in female rats. Experimental designs using rats should consider this result. The PFM, unlike the EUS, does not contribute to the bladder-to-urethra continence reflex. PFM strengthening may nonetheless facilitate urinary continence clinically by stabilizing the bladder neck.
Authors:
Hai-Hong Jiang; Levilester B Salcedo; Bo Song; Margot S Damaser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-03-05
Journal Detail:
Title:  Urology     Volume:  75     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-06-25     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1515.e1-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abdominal Muscles / innervation,  physiology
Animals
Disease Models, Animal
Electromyography
Endosonography
Female
Muscle Contraction / physiology
Pelvic Floor / innervation*,  physiology
Pressure
Random Allocation
Rats
Rats, Sprague-Dawley
Sensitivity and Specificity
Urethra / innervation*,  physiology
Urinary Bladder / innervation*,  physiology
Grant Support
ID/Acronym/Agency:
R01 HD038679/HD/NICHD NIH HHS; R01 HD038679-10/HD/NICHD NIH HHS; R01 HD38679-08/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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