| Pelvic floor muscles and the external urethral sphincter have different responses to applied bladder pressure during continence. | |
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MedLine Citation:
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PMID: 20206969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the functional innervation of the pelvic floor muscles (PFM) and whether there is PFM activity during an external pressure increase to the bladder in female rats. METHODS: Thirty-one female adult virgin Sprague-Dawley rats received an external increase in bladder pressure until urinary leakage was noted while bladder pressure was recorded (leak point pressure [LPP]) under urethane anesthesia. Six of the rats underwent repeat LPP testing after bilateral transection of the levator ani nerve. Another 6 rats underwent repeat LPP testing after bilateral transection of the pudendal nerve. Simultaneous recordings of PFM (pubo- and iliococcygeus muscles), electromyogram (EMG), and external urethral sphincter (EUS) EMG were recorded during cystometry and LPP testing. RESULTS: Thirteen rats (42%) showed tonic PFM EMG activity during filling cystometry. Eighteen rats (58%) showed no tonic PFM EMG activity at baseline, but PFM EMG could be activated by pinching the perineal skin. This activity could be maintained unless voiding occurred. The external increase in bladder pressure caused significantly increased EUS EMG activity as demonstrated by increased amplitude and frequency. However, there was no such response in PFM EMG. LPP was not significantly different after levator ani nerve transection, but was significantly decreased after pudendal nerve transection. CONCLUSIONS: PFM activity was not increased during external pressure increases to the bladder in female rats. Experimental designs using rats should consider this result. The PFM, unlike the EUS, does not contribute to the bladder-to-urethra continence reflex. PFM strengthening may nonetheless facilitate urinary continence clinically by stabilizing the bladder neck. |
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Authors:
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Hai-Hong Jiang; Levilester B Salcedo; Bo Song; Margot S Damaser |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-03-05 |
Journal Detail:
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Title: Urology Volume: 75 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-06-25 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 1515.e1-7 Citation Subset: IM |
Affiliation:
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Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Muscles
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innervation,
physiology Animals Disease Models, Animal Electromyography Endosonography Female Muscle Contraction / physiology Pelvic Floor / innervation*, physiology Pressure Random Allocation Rats Rats, Sprague-Dawley Sensitivity and Specificity Urethra / innervation*, physiology Urinary Bladder / innervation*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD038679-10/HD/NICHD NIH HHS; R01 HD38679-08/HD/NICHD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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