Document Detail

Pellagra secondary to 5-fluorouracil.
MedLine Citation:
PMID:  8504053     Owner:  NLM     Status:  MEDLINE    
The development of pellagra in a patient treated with 5-fluorouracil for malignant disease is reported. The aetiology of pellagra in this patient is discussed, and the reasons for possible under-diagnosis of pellagra in association with malignant disease considered. We report a patient who presented with the typical skin changes of pellagra. The rash, and an associated acute deterioration in cerebral function, were exacerbated by treatment with 5-fluorouracil. The importance of considering nicotinic-acid deficiency in patients with malignant disease has not been emphasized in the literature.
H P Stevens; L S Ostlere; R H Begent; J S Dooley; M H Rustin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  128     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-07     Completed Date:  1993-07-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  578-80     Citation Subset:  IM    
Department of Dermatology, Royal Free Hospital and School of Medicine, London, U.K.
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MeSH Terms
Biliary Tract Neoplasms / drug therapy
Fluorouracil / adverse effects*,  therapeutic use
Liver Neoplasms / drug therapy,  secondary
Nicotinic Acids / therapeutic use
Pellagra / chemically induced*,  drug therapy,  pathology
Skin / pathology
Reg. No./Substance:
0/Nicotinic Acids; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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