Document Detail

Pellagra: A Clinical, Histopathological, and Epidemiological Study of 7 Cases.
MedLine Citation:
PMID:  22456595     Owner:  NLM     Status:  Publisher    
BACKGROUND AND OBJECTIVES: In the developed world, pellagra is a rare condition that is restricted to a small number of at-risk groups. It mainly affects alcoholic patients and those with dietary deficiencies, with intestinal malabsorption, or in treatment with certain drugs. The aim of this study was to analyze the clinical, histopathological, and epidemiological characteristics of patients diagnosed with pellagra in our hospital and to compare the results with the findings traditionally described for this disease. PATIENTS AND METHODS: We undertook a retrospective study of patients with clinical or pathological evidence of pellagra who were seen in our hospital between 1998 and 2009. RESULTS: Seven patients met the inclusion criteria. All were men and the most common predisposing factors were alcoholism and dietary deficiency. All exhibited photosensitivity mainly affecting the forearms and the upper surface of the feet, where the lesions were more severe. The most consistent histopathological findings were the presence of dilated blood vessels with extravasation and little or no inflammatory infiltrate. Various changes were observed in the epidermis, including those suggestive of mild pellagra, such as epidermal pallor and some degree of ballooning of the keratinocytes. Other abnormalities such as epidermal necrosis and hyperkeratosis were also observed. In most patients, pellagra was not initially suspected. Additional noncutaneous findings were observed in almost all cases. CONCLUSIONS: Pellagra should be ruled out in patients with lesions on sun-exposed areas. Predisposing factors for pellagra should be assessed along with the social situation of patients and the presence of digestive or neurological abnormalities.
E Piqué-Duran; J A Pérez-Cejudo; D Cameselle; S Palacios-Llopis; O García-Vázquez
Related Documents :
20104405 - Auditory and visual impairments in patients with blast-related traumatic brain injury: ...
18940145 - Eosinophilic otitis media: a new middle ear disease entity.
17255885 - A clinical study of the efferent auditory system in patients with normal hearing who ha...
17762995 - Comparison of electronystagmography results with dynamic posturography findings in pati...
16929245 - Faecal bacterial mass and energetic losses in healthy humans and patients with a short ...
8333685 - Inferiorly based rectus abdominis flaps in critically ill and injured patients.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-26
Journal Detail:
Title:  Actas dermo-sifiliograficas     Volume:  -     ISSN:  1578-2190     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373062     Medline TA:  Actas Dermosifiliogr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier España, S.L. and AEDV. All rights reserved.
Sección de Dermatología, Hospital Dr. José Molina Orosa, Lanzarote, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analysis of Genetic Polymorphism of the HLA-B and HLA-DR Loci in Patients with Dermatophytic Onychom...
Next Document:  Thio-Pybox and Thio-Phebox complexes of chromium, iron, cobalt and nickel and their application in e...