Document Detail


Pegylated liposomal doxorubicin (PLD): enhanced skin toxicity in areas of vitiligo.
MedLine Citation:
PMID:  22275986     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pegylated liposomal doxorubicin (PLD, Doxil, Caelyx) is widely used for the treatment of ovarian cancer. It is a stable formulation encapsulating doxorubicin in a 'Stealth' (i.e., pegylated) liposome with a half-life of about 72 hours. This drastically altered pharmacology confers on it a considerably lower risk of cardiotoxicity, no acute emesis, and near absence of alopecia or problems with extravasation necrosis. On the other hand, PLD's dose-limiting toxicity is cutaneous. Since the original phase I report, cutaneous toxicities reported with PLD fall into four common categories: the well known hand-foot syndrome (also called palmoplantar erythrodysesthesia, or PPE), a diffuse follicular rash, intertrigo-like eruption, and hyperpigmentation including melanotic macules.
Authors:
Y Yuan; Sj Orlow; J Curtin; A Downey; F Muggia
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Publication Detail:
Type:  Journal Article     Date:  2008-12-09
Journal Detail:
Title:  Ecancermedicalscience     Volume:  2     ISSN:  1754-6605     ISO Abbreviation:  Ecancermedicalscience     Publication Date:  2008  
Date Detail:
Created Date:  2012-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392236     Medline TA:  Ecancermedicalscience     Country:  England    
Other Details:
Languages:  eng     Pagination:  111     Citation Subset:  -    
Affiliation:
NYU Cancer Institute and Medical Oncology, NYU Langone Medical Center, New York, NY 10016, USA.
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