Document Detail


Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein.
MedLine Citation:
PMID:  8563758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic and embryological studies in the mouse demonstrated functional differences between parental chromosomes during development. This is due to imprinted genes whose expression is dependent on their parental origin. In a recent systematic screen for imprinted genes, we detected Peg3 (paternally expressed gene 3). Peg3 is not expressed in parthenogenones. In interspecific hybrids, only the paternal copy of the gene is expressed in the embryos, individual tissues examined in d9.5-13.5 embryos, neonates and adults. Peg3 mRNA is a 9 kb transcript encoding an unusual zinc finger protein with eleven widely spaced C2H2 type motifs and two groups of amino acid repeats. Peg3 is expressed in early somites, branchial arches and other mesodermal tissues, as well as in the hypothalamus. Peg3 maps to the proximal region of chromosome 7. Consistent with our findings, maternal duplication of the proximal chromosome 7 causes neonatal lethality. This region is syntenic with human chromosome 19q13.1-13.3 (refs 10,11), where the genes for myotonic dystrophy and a putative tumour suppressor gene are located.
Authors:
Y Kuroiwa; T Kaneko-Ishino; F Kagitani; T Kohda; L L Li; M Tada; R Suzuki; M Yokoyama; T Shiroishi; S Wakana; S C Barton; F Ishino; M A Surani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature genetics     Volume:  12     ISSN:  1061-4036     ISO Abbreviation:  Nat. Genet.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-03-05     Completed Date:  1996-03-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  IM    
Affiliation:
Gene Research Center, Tokyo Institute of Technology, Yokohama, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF038939
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Animals, Newborn
Base Sequence
Brain Chemistry
Chromosome Banding
Female
Gene Expression Regulation, Developmental
Genomic Imprinting / genetics*
In Situ Hybridization, Fluorescence
Kruppel-Like Transcription Factors
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Molecular Sequence Data
Muridae / embryology
Protein Kinases*
Proteins / genetics*
RNA, Messenger / genetics
Sequence Analysis, DNA
Transcription Factors*
Zinc Fingers*
Chemical
Reg. No./Substance:
0/Kruppel-Like Transcription Factors; 0/PEG3 protein, human; 0/Peg3 protein, mouse; 0/Proteins; 0/RNA, Messenger; 0/Transcription Factors; EC 2.7.-/Protein Kinases

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