| Peering into early neurogenesis with embryonic stem cells. | |
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MedLine Citation:
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PMID: 11718855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Embryonic stem (ES) cells transplanted into the early mouse embryo have the capacity to differentiate into all cell types of the nervous system. A simplified culture system has been developed in which single ES cells transform into neural progenitor cells that go on to form neurospheres. This system is ideally suited for mechanistic studies of the earliest stages of neurogenesis. In this model, signaling via fibroblast growth factor and bone morphogenetic protein family members is important for the first steps of neural progenitor differentiation. |
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Authors:
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H Q Xian; D I Gottlieb |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in neurosciences Volume: 24 ISSN: 0166-2236 ISO Abbreviation: Trends Neurosci. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-11-23 Completed Date: 2002-01-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7808616 Medline TA: Trends Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 685-6 Citation Subset: IM |
Affiliation:
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Dept of Anatomy and Neurobiology, Box 8108, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology Fetus / cytology Nervous System / cytology, embryology* Neurons / cytology* Stem Cells / cytology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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