Document Detail

Pediatric urological causes of hypertension.
MedLine Citation:
PMID:  15711246     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We reviewed the association of hypertension with several common pediatric urological conditions. MATERIALS AND METHODS: We comprehensively reviewed the published literature linking hypertension with urinary tract infection, renal scarring, vesicoureteral reflux, multicystic dysplastic kidney, ureteropelvic junction obstruction and posterior urethral valves. RESULTS: Hypertension is a recognized sequela of several common pediatric urological conditions. It is thought to be a direct consequence of renal damage or scarring often resulting from vesicoureteral reflux and/or febrile urinary tract infection. Multicystic dysplastic kidney has rarely been shown to cause hypertension when examined in large series rather than as isolated case reports. Ureteropelvic junction obstruction and posterior urethral valves have been linked to hypertension, although to our knowledge no series to date has specifically examined this relationship and smaller retrospective reviews seldom describe associated hypertension. CONCLUSIONS: Several pediatric urological conditions are known to cause hypertension. However, methodological flaws in the literature, including a lack of standardized blood pressure followup, highly variable patient populations and poor control of concomitant urological abnormalities, greatly limit the ability to establish a causative link between any 1 specific condition and hypertension. Early diagnosis, the prevention of infection, close clinical followup and early intervention remain the primary means of preventing pediatric urological causes of hypertension.
Scott B Farnham; Mark C Adams; John W Brock; John C Pope
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of urology     Volume:  173     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-15     Completed Date:  2005-03-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  697-704     Citation Subset:  AIM; IM    
Department of Pediatric Surgery, Vanderbilt Children's Hospital, Nashville, Tennessee, USA
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MeSH Terms
Child, Preschool
Cicatrix / complications
Hypertension / etiology*
Urinary Tract Infections / complications
Urologic Diseases / complications*
Vesico-Ureteral Reflux / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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