Document Detail


Pediatric reference ranges for zinc protoporphyrin.
MedLine Citation:
PMID:  12554055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine pediatric reference ranges for zinc protoporphyrin (ZPP).
DESIGN AND METHODS: The study was conducted in a large pediatric hospital on patient blood specimens (n = 6,478) (0-17 y) accrued from January 2001 to June 2002. The data was analyzed employing the Hoffman approach, which was computer adapted.
RESULTS AND CONCLUSIONS: The 2.5(th) and 97.5(th) percentiles for children age 0 to 12 months were 9 to 40 microg/dL (16.6-73.6 micromol/mol heme) for female subjects and 8.5 to 34.5 microg/dL (15.6-63.5 micromol/mol heme) for males. The 97.5(th) percentiles decreased for the 13 to 24 months age group for females (32 microg/dL) (58.9 micromol/mol heme). There was a significant decrease in the 97.5(th) percentile for zinc protoporphyrin (ZPP) concentrations for the 5 to 9 yr age group, the 97.5(th) percentile being 30 microg/dL (55.2 micromol/mol heme) in both genders, which increased to 33.5 microg/dL (61.6 micromol/mol heme) in the 10 to 17 yr female age group but not for the males (31.5 microg/dL) (58.0 micromol/mol heme). The highest medians were 25.5 microg/dL (46.9 micromol/mol heme) for females, and 21.5 microg/dL (39.6 micromol/mol heme) for males in the 0 to 12 months age group.
Authors:
Offie Porat Soldin; Maureen Miller; Steven J Soldin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical biochemistry     Volume:  36     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-29     Completed Date:  2003-07-31     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  IM    
Affiliation:
Soldin Research and Consultants, Inc., Bethesda, MD, USA. offie@gwu.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Age Factors
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Lead Poisoning
Male
Protoporphyrins / blood*
Reference Values*
Time Factors
Grant Support
ID/Acronym/Agency:
R01 AG033867/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Protoporphyrins; 15442-64-5/zinc protoporphyrin
Comments/Corrections

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