Document Detail

Pediatric posterior reversible leukoencephalopathy syndrome and NSAID-induced acute tubular interstitial nephritis.
MedLine Citation:
PMID:  16504799     Owner:  NLM     Status:  MEDLINE    
Reversible posterior leukoencephalopathy syndrome is a recently described disorder with typical radiologic findings in the posterior regions of the cerebral hemisphere and cerebellum. The symptoms include headache, nausea, vomiting, visual disturbances, focal neurologic deficits, and seizures. A 10-year-old male was hit on his back, resulting in backache. He was medicated with sodium diclofenate and mefenamic acid. The next day, he had edema and oliguria. By the third day, his blood pressure increased and he began to experience restlessness and worsening mental status. He then complained of headache and visual disturbances and had a seizure. A magnetic resonance imaging scan revealed abnormalities in the posterior regions of the cerebral hemisphere and cerebellum. The patient was treated with antiepileptics and calcium antagonists. His hypertension and seizures were well controlled. On the 22nd day, he was discharged without any neurologic or renal deficits. Reversible posterior leukoencephalopathy syndrome does not occur frequently in childhood, and this is the first case report of reversible posterior leukoencephalopathy syndrome related to nonsteroidal anti-inflammatory drugs. One should consider reversible posterior leukoencephalopathy syndrome as a side effect of nonsteroidal anti-inflammatory drug use in daily medical treatment.
Shoji Yokobori; Hiroyuki Yokota; Yasuhiro Yamamoto
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  34     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-28     Completed Date:  2006-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Acute Disease
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  adverse effects*
Back Injuries / drug therapy*
Back Pain / drug therapy*
Cerebral Cortex / drug effects,  pathology
Diclofenac / administration & dosage,  adverse effects*
Drug Therapy, Combination
Follow-Up Studies
Hypertensive Encephalopathy / chemically induced*,  diagnosis
Image Enhancement
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Mefenamic Acid / administration & dosage*,  adverse effects
Nephritis, Interstitial / chemically induced*,  diagnosis
Occipital Lobe / drug effects*,  pathology
Parietal Lobe / drug effects*,  pathology
Remission, Spontaneous
Wounds, Nonpenetrating / drug therapy*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 15307-86-5/Diclofenac; 61-68-7/Mefenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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