| Pediatric nodal marginal zone lymphoma may develop in the adult population. | |
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MedLine Citation:
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PMID: 19863176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pediatric nodal marginal zone lymphoma (NMZL) is described as a separate variant of NMZL in the most recent WHO classification of tumors of hematologic and lymphoid tissues. It has distinctive morphology and clinical presentation and stands out as an indolent disease with remarkably better overall prognosis compared to classic NMZL. Here we report two adult patients with NMZL with clinical and morphologic features consistent with pediatric NMZL (pNMZL) and review available literature describing the clinical and histologic presentation of pNMZL. Two men, ages 44 and 18 years, each presented with localized cervical lymphadenopathy, both demonstrated florid proliferation of the marginal zone and disruption of reactive germinal centers, progressive transformation of germinal centers-like morphologic features typical for pNMZL and clonal disease with immunophenotype consistent with NMZL. This is the first report of pNMZL in a middle-aged person. Distinct histologic features and characteristic benign clinical course will help to distinguish this rare variant from other NMZL in the adults. Clinically, recognition is important to understand the true incidence of this rare form in the adult population and to avoid unnecessary overtreatment of this indolent form. |
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Authors:
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Elena Gitelson; Tahseen Al-Saleem; Valentin Robu; Michael M Millenson; Mitchell R Smith |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 51 ISSN: 1029-2403 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-08 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 89-94 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Fox Chase Cancer Center, PA 19111, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibodies, Monoclonal / therapeutic use Antineoplastic Agents / therapeutic use Flow Cytometry / methods Humans Immunophenotyping Immunotherapy / methods Lymphatic Diseases / diagnosis, pathology Lymphoma, B-Cell, Marginal Zone / diagnosis*, immunology, surgery, therapy Male Medical Oncology / methods* Prognosis Remission Induction Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antineoplastic Agents; 0/rituximab |
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