| Pediatric nephrotic syndrome: from the simple to the complex. | |
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MedLine Citation:
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PMID: 19615560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Remarkable advances have been made in the past decade in understanding the pathophysiology of idiopathic nephrotic syndrome. Although the initiating events leading to the onset of proteinuria still are not well defined, it has become increasingly clear that many glomerular diseases can be classified as podocytopathies, with injury to the podocyte playing a major role in the development and progression of disease. A complex interaction of immune system mediators, slit diaphragm signal transduction, podocyte injury and conformational change, and mediators of apoptosis and fibrosis determine the extent and nature of proteinuria and progression of glomerulosclerosis. New insights into the pathogenesis of idiopathic nephrotic syndrome likely will lead to innovative therapies and new approaches to management and prevention. |
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Authors:
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Jerome C Lane; Frederick J Kaskel |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in nephrology Volume: 29 ISSN: 1558-4488 ISO Abbreviation: Semin. Nephrol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 389-98 Citation Subset: IM |
Affiliation:
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Division of Kidney Diseases, Department of Pediatrics, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614, USA. j-lane@northwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Disease Progression Glomerulosclerosis, Focal Segmental / complications*, genetics, physiopathology Humans Intracellular Signaling Peptides and Proteins / genetics, metabolism, physiology Membrane Proteins / genetics, metabolism, physiology Nephrosis, Lipoid / complications*, genetics, physiopathology Nephrotic Syndrome / genetics, pathology, physiopathology* Podocytes / pathology Proteinuria / physiopathology Signal Transduction / genetics |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/NPHS2 protein; 0/nephrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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