| Pediatric myelodysplastic syndrome with cytoplasmic vacuolation in myeloid precursors. | |
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MedLine Citation:
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PMID: 21178710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 6-year-old boy presented with pancytopenia. Bone marrow morphology showed dyspoiesis and cytoplasmic vacuolation in myeloid precursor cells. Cytoplasmic vacuoles are described in erythroid cells in myelodysplastic syndrome (MDS) but are extremely rare in myeloid precursor cells. We ruled out viral and autoimmune etiology, hypocupremia, Pearson syndrome, and chromosomal abnormalities. Finally, a diagnosis of MDS of refractory cytopenia of childhood subtype was made. The patient then underwent an allogenic stem cell transplant that resulted in normalization of the complete blood counts and bone marrow morphology. However, he later developed late graft failure; this was followed by a second transplant after which he died of sepsis and multiorgan failure. The case is presented here for the rare morphologic features, hitherto not earlier described in pediatric MDS. |
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Authors:
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Dipanjan Panda; Nidhi Gupta; Ritu Gupta; Sameer Bakhshi |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 33 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-23 Completed Date: 2011-02-18 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 59-61 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Dr B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Cytoplasm / drug effects, pathology* Fatal Outcome Hematopoietic Stem Cell Transplantation Humans Male Myelodysplastic Syndromes / diagnosis*, therapy Myeloid Progenitor Cells / drug effects, pathology* Transplantation, Homologous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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