| Pediatric multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 19364455 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The diagnosis of multiple sclerosis (MS) in a child remains challenging, given the limited diagnostic criteria and the somewhat poorly defined overlap with acute disseminated encephalomyelitis. Although there are many similarities between pediatric-onset and adult-onset MS, an earlier age at disease presentation seems to be associated with specific features such as more frequent encephalopathy, seizures, and brainstem and cerebellar symptoms during the first event. In addition, the initial brain MRI scan of younger patients shows more frequent involvement of the posterior fossa and higher numbers of ovoid, ill-defined T2-bright foci that often partially resolve on the follow-up scan, thereby challenging early diagnosis. Finally, the spinal fluid in younger patients may fail to reveal oligoclonal bands or elevated IgG index at disease onset. No therapy for MS in children has been approved by the US Food and Drug Administration. As a result, physicians have started to use off-label drugs approved for adults. Recent data suggest that some children experience a disease breakthrough on first-line therapies approved for adult MS, and thus second-line therapies must be considered. |
| | |
Authors:
|
Emmanuelle Waubant; Dorothee Chabas |
Related Documents
:
|
2182855 - Nongastrointestinal adverse reactions to nsaid. 20571825 - Clinical practice: drug desensitization in children. 16621785 - Place and space: the where and why of drug-use location among rural african american wo... 10488905 - Complications and costs of treatment of refractory generalized convulsive status epilep... 2755105 - Narrative analysis: clinical applications of story generation and story retelling. 1081205 - Experience with dimer-x 1-ventriculography. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current treatment options in neurology Volume: 11 ISSN: 1092-8480 ISO Abbreviation: Curr Treat Options Neurol Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815940 Medline TA: Curr Treat Options Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 203-10 Citation Subset: - |
Affiliation:
|
Emmanuelle Waubant, MD, PhD University of California San Francisco, Regional Pediatric Multiple Sclerosis Center, 350 Parnassus Avenue, Suite 908, San Francisco, CA 94117, USA. emmanuelle.waubant@ucsf.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinically isolated syndrome and multiple sclerosis: rethinking the arsenal.
Next Document: Monoclonal antibody treatments for multiple sclerosis.