Document Detail

Pediatric mitral valve replacement: incremental risk factors impacting survival and reintervention.
MedLine Citation:
PMID:  15792174     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM OF THE STUDY: Predictors of survival and reintervention in children undergoing mitral valve replacement (MVR) were assessed. METHODS: A total of 37 children underwent MVR, with a mean prosthesis size of 22.5 mm. RESULTS: Six patients died during the study. Actuarial and event-free survivals (including operative mortality) at 10 and 20 years were 85 and 85%, and 55 and 37%, respectively. The linearized rate of bleeding was 0.67% per patient-year (pt-yr). There were no instances of thromboembolism, endocarditis or structural valve dysfunction. Six patients required reintervention for somatic outgrowth at a mean postoperative interval of 104 months. Freedom from reintervention at five, 10 and 20 years was 92, 73 and 48%, respectively. There were no deaths or complications following reintervention. The mean follow up was 96 months (range: 3 to 276 months); total cumulative follow up was 296 pt-yr. Multivariate predictors of mortality were age < 6 months, NYHA class IV, congestive cardiac failure, internal orifice diameter (IOD) < 14 mm and effective orifice area (EOA) < 1.5 cm2. Predictors for reintervention were age < 6 months (p = 0.0021), predicted annulus size < 16 mm (p < 0.0001), IOD < 18 mm (p = 0.05), IOD index (IODI) > 50 mm/m2 (p = 0.007), EOA < 2.5 cm2 (p = 0.05), EOA index (EOAI) > 7 cm2/m2 (p < 0.0001) and prosthesis size-body surface area (BSA) index (SI) > 69 mm/m2 (p = 0.007). CONCLUSION: Early mortality occurs in neonates and infants with associated lesions, particularly atrioventricular septal defect. Risk factors for mortality include age, NYHA class, and small IOD and EOA. Risk factors for reintervention include age < 6 months, small predicted annulus size, IOD and EOA, IODI > 50 mm/m2, EOAI > 7 cm2/m2 and SI > 69 mm/m2.
Ganesh Shanmugam; Kenneth MacArthur; James Pollock
Related Documents :
7949664 - Initial clinical experience with the toronto stentless porcine valve.
18414344 - Comparison of the effects of aortic valve replacement using 19-mm carpentier-edwards pe...
6772334 - Porcine xenograft valves. long-term (60-89-month) follow-up.
96684 - Structural changes in glutaraldehyde-treated porcine heterografts used as substitute ca...
3239574 - Effect of mazindol on growth hormone levels in patients with duchenne muscular dystrophy.
23989534 - Morphological features of the p-waves at surface electrocardiogram as surrogate to mech...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  14     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-28     Completed Date:  2005-09-13     Revised Date:  2006-05-04    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  158-65     Citation Subset:  IM    
Department of Cardiac Surgery, Royal Hospital for Sick Children, Glasgow, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Child, Preschool
Heart Valve Diseases / mortality*,  surgery*
Heart Valve Prosthesis* / adverse effects
Postoperative Complications / mortality
Risk Factors
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Valve replacement in women of childbearing age: influences on mother, fetus and neonate.
Next Document:  Mechanical aortic valve replacement: long-term outcomes in children.