| Pediatric macrophagic myofasciitis associated with motor delay. | |
| | |
MedLine Citation:
|
PMID: 16866298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Macrophagic myofasciitis (MMF) is a rare inflammatory myopathy characterized by accumulation of perifascicular macrophages without muscle fiber necrosis. Few sporadic pediatric cases have been described, and MMF is recognized as a possible reaction to intramuscular injections of aluminum-containing vaccines. The association of MMF and motor delay is unclear in the pediatric population. We report the clinical evaluation and follow-up of 4 young children with MMF and review of 4 cases previously reported of sporadic, pediatric MMF to better determine the possible association of sporadic MMF in children presenting with motor delay. PATIENTS AND METHODS: Described our 4 case reports in which we observed children presenting for evaluation of motor delay with unrevealing clinical and laboratory evaluations for common causes of motor delay and histopathological evaluations consistent with macrophagic myofasciitis. Muscle data was obtained by quadriceps muscle biopsy. RESULTS: Clinical presentations were similar in all children and were characterized by motor delay, hypotonia, and failure to thrive with an unrevealing evaluation for central nervous system disease, congenital, and mitochondrial myopathies. CONCLUSIONS: Our cases and those previously reported in the literature demonstrate MMF should be considered in the evaluation of children with failure to thrive, hypotonia, and muscle weakness, as clinical outcome appears to be favorable. |
| | |
Authors:
|
K L Gruis; J W Teener; M Blaivas |
Related Documents
:
|
17701788 - Hyperprolactinaemia. 10567888 - Giant retroperitoneal hemangiopericytoma with paraneoplastic gynecomastia. case report ... 9491118 - Dermatologic electrosurgery in patients with implantable cardioverter-defibrillators an... 12065378 - Thymoma and myotonic dystrophy: successful treatment with chemotherapy and radiation: c... 15841738 - Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis. 14692478 - Cases from the aerospace medicine residents' teaching file. transient ischemic attack i... |
Publication Detail:
|
Type: Case Reports; Journal Article; Review |
Journal Detail:
|
Title: Clinical neuropathology Volume: 25 ISSN: 0722-5091 ISO Abbreviation: Clin. Neuropathol. Publication Date: 2006 Jul-Aug |
Date Detail:
|
Created Date: 2006-07-26 Completed Date: 2006-09-07 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8214420 Medline TA: Clin Neuropathol Country: Germany |
Other Details:
|
Languages: eng Pagination: 172-9 Citation Subset: IM |
Affiliation:
|
Department of Neurology, University of Michigan Health System, Ann Arbor, MI, USA. kgruis@umich.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biopsy Developmental Disabilities / etiology*, immunology, pathology Fasciitis / complications*, immunology, pathology Female Humans Infant Macrophages / pathology* Male Motor Skills Disorders / etiology*, immunology, pathology Muscle Fibers, Skeletal / immunology, pathology Muscle Hypotonia / etiology, immunology, pathology Myositis / complications*, immunology, pathology Myositis, Inclusion Body / complications, immunology, pathology Quadriceps Muscle / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A vicious circle: role of oxidative stress, intraneuronal Abeta and Cu in Alzheimer's disease.
Next Document: Adult central core disease. Clinical, histologic and genetic aspects: case report and review of the ...