Document Detail


Pediatric low-grade gliomas: how modern biology reshapes the clinical field.
MedLine Citation:
PMID:  24589977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas.
Authors:
Guillaume Bergthold; Pratiti Bandopadhayay; Wenya Linda Bi; Lori Ramkissoon; Charles Stiles; Rosalind A Segal; Rameen Beroukhim; Keith L Ligon; Jacques Grill; Mark W Kieran
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2014-02-28
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1845     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-21     Completed Date:  2014-06-13     Revised Date:  2014-07-07    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  294-307     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / genetics
Brain Neoplasms / epidemiology,  genetics,  pathology*,  therapy*
Cell Survival / genetics
Epigenesis, Genetic / genetics
Glioma / epidemiology,  genetics,  pathology*,  therapy*
Humans
Molecular Targeted Therapy
Neoplasm Grading
Pediatrics
Prognosis
Grant Support
ID/Acronym/Agency:
P01 CA142536/CA/NCI NIH HHS; P01 NS047572/NS/NINDS NIH HHS; P01CA142536/CA/NCI NIH HHS; P01NS047572/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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