| Pediatric juvenile polyposis syndromes: an update. | |
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MedLine Citation:
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PMID: 19463221 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Colon polyps are a common finding in pediatrics and can present with rectal bleeding, abdominal pain, or polyp prolapse from the rectum. Histologically classified as hamartomas, these isolated pediatric polyps lack epithelial dysplasia and have no cancer risk. However, when polyps are present in greater numbers, or are associated with a family history of polyps or colon or other cancers, a polyposis or hereditary colorectal cancer syndrome should be considered. Using a case-based format, this article reviews the clinical features and provides updates on the three most common hamartomatous polyp syndromes of childhood: juvenile polyposis syndrome, Peutz-Jeghers syndrome, and the PTEN hamartoma tumor syndrome. Each syndrome has distinctive intestinal and extra-intestinal findings that, when present, can guide genetic counseling and testing. Lifelong cancer surveillance is crucial to disease prevention and the long-term health of these patients and their families. |
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Authors:
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Sherry C Huang; Steven H Erdman |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Current gastroenterology reports Volume: 11 ISSN: 1534-312X ISO Abbreviation: Curr Gastroenterol Rep Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-08-11 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 211-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenomatous Polyposis Coli
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diagnosis*,
genetics Adolescent Biopsy Bone Morphogenetic Protein Receptors, Type I / genetics Child Child, Preschool Colonoscopy / methods DNA, Neoplasm / genetics Diagnosis, Differential Female Genetic Predisposition to Disease* Hamartoma / diagnosis*, genetics Humans Male Mutation PTEN Phosphohydrolase / genetics Peutz-Jeghers Syndrome / diagnosis*, genetics Protein-Serine-Threonine Kinases / genetics Smad4 Protein / genetics |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/SMAD4 protein, human; 0/Smad4 Protein; EC 2.7.1.-/STK11 protein, human; EC 2.7.1.37/BMPR1A protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.30/Bone Morphogenetic Protein Receptors, Type I; EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN Phosphohydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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