Document Detail


Pediatric heart transplantation: results of 2- and 5-year follow-up.
MedLine Citation:
PMID:  7947878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pediatric heart transplantation has become an accepted method of treatment for certain pediatric heart disease. From July 1986 to January 1993, we performed 25 orthotopic pediatric heart transplantations at the University of Minnesota Hospital and Clinics in 16 male patients and nine female patients. The average age was 8.5 years with a range from 7 days to 18 years. Three of the patients were younger than 1 year of age. The indications for transplantation included congenital heart disease in six patients and cardiomyopathy in 19 patients. Four of the patients with congenital heart disease had previously undergone a cardiac surgical procedure. Two patients with cardiomyopathy had mechanical assist devices in place at the time of transplantation. Donor age ranged from 2 months to 36 years. The donor organ ischemic time ranged from 60 minutes to 329 minutes, with an average of 191 minutes. Follow-up ranged from 6 to 84 months. Overall, there were seven deaths (28%) in the patients undergoing transplantation. Of the seven deaths, four (16%) were early (within 30 days) and three (14.3%) were late. The four early deaths were a result of donor organ failure, and the three late deaths a result of acute rejection. The 2-year survival for patients with a minimum 24-month evaluation was 79% (15 of 19). Of 12 patients available for 5-year assessment, 75% (9 of 12) were alive and doing well at the time this article was written. Pediatric heart transplantation can provide good intermediate and long-term survival for selected pediatric patients.
Authors:
M S Slaughter; E Braunlin; R M Bolman; J E Molina; S J Shumway
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  13     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:    1994 Jul-Aug
Date Detail:
Created Date:  1994-12-07     Completed Date:  1994-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  624-30     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular and Thoracic Surgery, University of Minnesota, Minneapolis 55455.
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MeSH Terms
Descriptor/Qualifier:
Cardiomyopathies / mortality,  surgery*
Child
Female
Follow-Up Studies
Graft Rejection / mortality,  prevention & control
Graft Survival
Heart Defects, Congenital / mortality,  surgery*
Heart Transplantation / mortality*,  statistics & numerical data
Humans
Immunosuppressive Agents / therapeutic use
Male
Survival Rate
Time Factors
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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