Document Detail

Pediatric gastroesophageal reflux disease and acid-related conditions: trends in incidence of diagnosis and acid suppression therapy.
MedLine Citation:
PMID:  19827992     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe the incidence of diagnosis of gastroesophageal reflux disease and acid-related conditions (GERD/ARC) throughout childhood and characterize patterns of diagnosis and treatment with proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H(2)RAs).
METHODS: Cohorts of GERD/ARC children (age 0-18 years) were identified from a large US administrative claims database covering 1999-2005 using ICD-9 codes. Incidence, healthcare utilization (HCU), costs, therapy discontinuation and switching rates were compared between various age and patient groups.
RESULTS: Between 2000 and 2005 annual incidence of GERD/ARC diagnosis among infants (age ≤1 year) more than tripled (from 3.4 to 12.3%) and increased by 30% to 50% in other age groups. Patients diagnosed by GI specialists (9.2%) were more likely to be treated with PPIs compared to patients diagnosed by primary care physician (PCP). PPI-initiated patients doubled (from 31.5% in 1999 to 62.6% in 2005) and, when compared with H(2)RA-initiated patients, were associated with 30% less discontinuation and 90% less therapy switching in the first month, and with higher comorbidity burden and pre-treatment total HCU and costs when diagnosed by GI specialists.
LIMITATIONS: The use of an exploratory definition for GERD/ARC, administrative claims data and potential coding errors in diagnosis codes used in selection process may limit the generalizability of the results.
CONCLUSIONS: GERD/ARC incidence increased for children of all ages between 2000 and 2005. PCPs made the majority of diagnoses. PPI initiations have now surpassed H(2)RA initiations.
S P Nelson; S Kothari; E Q Wu; N Beaulieu; J M McHale; O H Dabbous
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical economics     Volume:  12     ISSN:  1941-837X     ISO Abbreviation:  J Med Econ     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-16     Completed Date:  2011-05-24     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9892255     Medline TA:  J Med Econ     Country:  England    
Other Details:
Languages:  eng     Pagination:  348-55     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Costs and Cost Analysis
Gastroenteritis / diagnosis,  drug therapy*,  economics,  epidemiology*
Gastroesophageal Reflux / diagnosis,  drug therapy*,  economics,  epidemiology*
Histamine H2 Antagonists / economics,  therapeutic use*
Infant, Newborn
Insurance Claim Review
Logistic Models
Proton Pump Inhibitors / economics,  therapeutic use*
United States / epidemiology
Reg. No./Substance:
0/Histamine H2 Antagonists; 0/Proton Pump Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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