| Pediatric focal epilepsy syndromes. | |
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MedLine Citation:
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PMID: 23027100 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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SUMMARY:: Benign epilepsy with centrotemporal spikes, early-onset childhood occipital epilepsy (Panayiotopoulos syndrome [PS]) and late-onset childhood occipital epilepsy (Gastaut type [LOCE-G]) are the principal pediatric focal epilepsy syndromes. They share major common characteristics: the appearance and resolution of electroclinical features are age related, there is a strong genetic predisposition, the clinical course is often mild with infrequent and easy to control seizures, interictal epileptiform activity is disproportionately abundant when compared with the clinical correlate, and tends to potentiate and generalize during sleep. In this review, we outline the relevant pathophysiology underlying this electroclinical spectrum. Then, the initial description of individual syndromes is followed by a summary of overlapping features and intermediate presentations that question the boundaries between these entities and provide the basis for the concept of a childhood seizure susceptibility syndrome. Additionally, we outline the main features of the related epileptic encephalopathies. An outlook on potential future lines of research completes this review. |
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Authors:
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Iván Sánchez Fernández; Tobias Loddenkemper |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society Volume: 29 ISSN: 1537-1603 ISO Abbreviation: J Clin Neurophysiol Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506708 Medline TA: J Clin Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 425-40 Citation Subset: IM |
Affiliation:
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*Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A. †Department of Child Neurology, Hospital Sant Joan de Déu, Universidad de Barcelona, Barcelona, Spain. |
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