Document Detail


Pediatric asthmatic patients have low serum levels of monocyte chemoattractant protein-1.
MedLine Citation:
PMID:  16801146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum levels of MCP-1 were measured in children with and without asthma in order to determine a possible correlation between the MCP-1-2518A/G polymorphism, serum levels of MCP-1 and asthma. Two groups of subjects -160 children with asthma and 158 healthy children were screened with a PCR-based genotyping assay. Serum MCP-1 level was measured by ELISA. The -2518G allele occurred at a significantly higher frequency in asthmatic children than in controls. The mean serum MCP-1 level was significantly lower in the asthmatic than in the control children. There was no significant association between the MCP-1 genotypes and the serum MCP-1 levels.
Authors:
Márton Keszei; Adrienne Nagy; Gergely T Kozma; Károly Radosits; Gergely Tölgyesi; András Falus; Csaba Szalai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  43     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:    2006 Jun-Jul
Date Detail:
Created Date:  2006-06-27     Completed Date:  2006-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-404     Citation Subset:  IM    
Affiliation:
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Asthma / blood*,  complications
Chemokine CCL2 / blood*,  genetics
Child
Child, Preschool
Chlamydophila Infections / complications
Enzyme-Linked Immunosorbent Assay
Female
Glucocorticoids / therapeutic use
Humans
Male
Polymorphism, Genetic
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Chemokine CCL2; 0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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