| Pediatric applications of inulin and oligofructose. | |
| | |
MedLine Citation:
|
PMID: 17951508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Inulin-type fructans have been used in infants and children because of their prebiotic potential to modulate the intestinal flora and influence the innate and adaptive immune response favorably. A mixture of long chain inulin (5-60 monomers) in combination with galactooligosaccharides (GOS) (2-7 monomers) has been added to infant formula in Europe in a 10-90% ratio for over 5 y. Clinical studies have demonstrated that these prebiotic formulas have significant effects on flora composition, improve stool consistency, decrease intestinal permeability, and reduce the incidence of gastrointestinal (GI) and respiratory infections and atopic dermatitis. Oligofructose in weaning foods consumed by toddlers increases fecal Bifidobacteria counts and decreases fecal Clostridia counts during consumption, leading to softer stools and fewer fever episodes and other GI symptoms. Synergy, a mixture of oligofructose and long chain inulin, is protective of the Bifidus flora during amoxicillin treatment. Few studies are available in adolescents. Calcium absorption is improved especially by Synergy. The same product, combined with Lactobacillus Rhamnosus and Acidophilus, induces significantly favorable effects on colonic ammonia (NH3) metabolism. The demonstrated bifidogenic effect of inulin and oligofructose on intestinal microbiota is probably not the only mechanism involved but may be the key to important immune mediated effects. |
| | |
Authors:
|
Gigi Veereman |
Related Documents
:
|
20830598 - Liquid barium is not representative of infant formula: characterisation of rheological ... 10232648 - Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology... 19350978 - Evaluation of an antimicrobial ingredient prepared from a lactobacillus acidophilus cas... 1905478 - Effect of early introduction of formula vs fat-free parenteral nutrition on essential f... 8285778 - Sleeping position for infants and cot death in the netherlands 1985-91. 22253708 - Remarkable rates of lightning strike mortality in malawi. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The Journal of nutrition Volume: 137 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-10-22 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 2585S-2589S Citation Subset: IM |
Affiliation:
|
Pediatric Gastroenterology and Nutrition, Queen Paola Children's Hospital-ZNA, 2020 Antwerp, Belgium. gveereman@skynet.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bifidobacterium
/
drug effects*,
immunology Child, Preschool Humans Immune System / drug effects* Infant Infant Food / microbiology* Infant, Newborn Intestinal Mucosa* / drug effects, immunology, microbiology Inulin* / administration & dosage, immunology, pharmacology Oligosaccharides* / administration & dosage, immunology, pharmacology Pediatrics* |
| Chemical | |
Reg. No./Substance:
|
0/Oligosaccharides; 0/oligofructose; 9005-80-5/Inulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans.
Next Document: Inulin-type fructans in healthy aging.