Document Detail

Pediatric applications of inulin and oligofructose.
MedLine Citation:
PMID:  17951508     Owner:  NLM     Status:  MEDLINE    
Inulin-type fructans have been used in infants and children because of their prebiotic potential to modulate the intestinal flora and influence the innate and adaptive immune response favorably. A mixture of long chain inulin (5-60 monomers) in combination with galactooligosaccharides (GOS) (2-7 monomers) has been added to infant formula in Europe in a 10-90% ratio for over 5 y. Clinical studies have demonstrated that these prebiotic formulas have significant effects on flora composition, improve stool consistency, decrease intestinal permeability, and reduce the incidence of gastrointestinal (GI) and respiratory infections and atopic dermatitis. Oligofructose in weaning foods consumed by toddlers increases fecal Bifidobacteria counts and decreases fecal Clostridia counts during consumption, leading to softer stools and fewer fever episodes and other GI symptoms. Synergy, a mixture of oligofructose and long chain inulin, is protective of the Bifidus flora during amoxicillin treatment. Few studies are available in adolescents. Calcium absorption is improved especially by Synergy. The same product, combined with Lactobacillus Rhamnosus and Acidophilus, induces significantly favorable effects on colonic ammonia (NH3) metabolism. The demonstrated bifidogenic effect of inulin and oligofructose on intestinal microbiota is probably not the only mechanism involved but may be the key to important immune mediated effects.
Gigi Veereman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  137     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2585S-2589S     Citation Subset:  IM    
Pediatric Gastroenterology and Nutrition, Queen Paola Children's Hospital-ZNA, 2020 Antwerp, Belgium.
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MeSH Terms
Bifidobacterium / drug effects*,  immunology
Child, Preschool
Immune System / drug effects*
Infant Food / microbiology*
Infant, Newborn
Intestinal Mucosa* / drug effects,  immunology,  microbiology
Inulin* / administration & dosage,  immunology,  pharmacology
Oligosaccharides* / administration & dosage,  immunology,  pharmacology
Reg. No./Substance:
0/Oligosaccharides; 0/oligofructose; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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