| Pediatric uveitis secondary to probable, presumed, and biopsy-proven sarcoidosis. | |
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MedLine Citation:
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PMID: 20506967 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To describe pediatric patients with uveitis diagnosed as having sarcoidosis. METHODS: Medical records of pediatric patients evaluated between 1987 and 2008 were reviewed to identify those with ocular inflammation in whom a diagnosis of sarcoidosis was considered. A classification system including ocular findings and results of laboratory testing was devised and used to classify likelihood of sarcoidosis. RESULTS: Four hundred sixty children younger than 17 years were evaluated. Based on the classification system designed, 13 patients (2.8%) had probable, presumed, or definite sarcoidosis. The mean age was 11.6 years (range: 5 to 16 years). Elevated angiotensin-converting enzyme was measured in 6 patients and lysozyme in 5 patients. Five of 12 patients in whom chest imaging was performed had signs of sarcoidosis. Anterior segment involvement was non-granulomatous more often than granulomatous. Seven patients had multifocal choroiditis and 4 patients had retinal periphlebitis. CONCLUSION: Ocular sarcoidosis is uncommon in children, even at a tertiary referral center. Pulmonary involvement was detected in slightly less than half of the patients who had imaging, in contrast to previous reports of almost universal lung involvement in children 8 to 15 years old. The classification system of presumed, probable, and definite sarcoidosis presented may be useful in clinical practice. |
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Authors:
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Daniel E Choi; Andrea D Birnbaum; Frederick Oh; Howard H Tessler; Debra A Goldstein |
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Publication Detail:
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Type: Journal Article Date: 2010-05-21 |
Journal Detail:
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Title: Journal of pediatric ophthalmology and strabismus Volume: 48 ISSN: 1938-2405 ISO Abbreviation: J Pediatr Ophthalmol Strabismus Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7901143 Medline TA: J Pediatr Ophthalmol Strabismus Country: United States |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Copyright Information:
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Copyright 2011, SLACK Incorporated. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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