Document Detail


Pediatric and Perinatal Pathology: SY21-1 ALLOIMMUNE DISORDERS OF PREGNANCY.
MedLine Citation:
PMID:  25188137     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
There is mounting evidence that several placental pathologic entities associated with fetal intrauterine growth restriction and poor and recurrent pregnancy outcomes reflect disruption of mechanisms of immune tolerance normally operative during pregnancy. This presentation update will include an overview studies that have yielded evidence of the role of alloimmune mechanisms, or host-versus-graft response, in the pathogenesis and adverse outcomes associated with these disorders. In addition, new evidence for the potential role of the generation of fetal antigen specific antibodies, activation of the classic complement pathway, c4d fragment formation, and the histopathologic significance of plasmacytic deciduitis, as an indicator of maternal rejection of the fetus, will be presented. Finally, the potential overlap of the role of some of these immunemediated mechanisms in the pathogenesis of preeclampsia and its associated placental pathologies will be briefly discussed.
Authors:
Ona Marie Faye-Petersen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology     Volume:  46 Suppl 2     ISSN:  1465-3931     ISO Abbreviation:  Pathology     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-09-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0175411     Medline TA:  Pathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  S32     Citation Subset:  IM    
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