Document Detail

Pediatric In Vitro and In Silico Models of Deposition via Oral and Nasal Inhalation.
MedLine Citation:
PMID:  24870701     Owner:  NLM     Status:  In-Data-Review    
Abstract Respiratory tract deposition models provide a useful method for optimizing the design and administration of inhaled pharmaceutical aerosols, and can be useful for estimating exposure risks to inhaled particulate matter. As aerosol must first pass through the extrathoracic region prior to reaching the lungs, deposition in this region plays an important role in both cases. Compared to adults, much less extrathoracic deposition data are available with pediatric subjects. Recently, progress in magnetic resonance imaging and computed tomography scans to develop pediatric extrathoracic airway replicas has facilitated addressing this issue. Indeed, the use of realistic replicas for benchtop inhaler testing is now relatively common during the development and in vitro evaluation of pediatric respiratory drug delivery devices. Recently, in vitro empirical modeling studies using a moderate number of these realistic replicas have related airway geometry, particle size, fluid properties, and flow rate to extrathoracic deposition. Idealized geometries provide a standardized platform for inhaler testing and exposure risk assessment and have been designed to mimic average in vitro deposition in infants and children by replicating representative average geometrical dimensions. In silico mathematical models have used morphometric data and aerosol physics to illustrate the relative importance of different deposition mechanisms on respiratory tract deposition. Computational fluid dynamics simulations allow for the quantification of local deposition patterns and an in-depth examination of aerosol behavior in the respiratory tract. Recent studies have used both in vitro and in silico deposition measurements in realistic pediatric airway geometries to some success. This article reviews the current understanding of pediatric in vitro and in silico deposition modeling via oral and nasal inhalation.
Nicholas B Carrigy; Conor A Ruzycki; Laleh Golshahi; Warren H Finlay
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of aerosol medicine and pulmonary drug delivery     Volume:  27     ISSN:  1941-2703     ISO Abbreviation:  J Aerosol Med Pulm Drug Deliv     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-05-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101475057     Medline TA:  J Aerosol Med Pulm Drug Deliv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-69     Citation Subset:  T    
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