Document Detail

Pediatric HIV infection: neurologic and neuropsychologic findings.
MedLine Citation:
PMID:  7833564     Owner:  NLM     Status:  MEDLINE    
Neurologic and neuropsychologic findings are early and important prognostic indicators of symptomatic HIV disease among infants and young children. The most common presentations include progressive encephalopathy, loss of motor milestones, and corticospinal tract abnormalities. It is hypothesized that, in some instances, the more severe neurologic manifestations of HIV noted in infancy may reflect the consequences of in utero HIV infection, or the increased vulnerability of infants to HIV infection during a time of rapid brain growth. Current research suggests that infants with basal ganglia calcification and those with plummeting or low CD4+ counts are at particular risk of severe central nervous disease progression. In contrast to infants and toddlers, older children and adolescents appear to demonstrate only subtle neurologic dysfunction until very late in their illness. Findings seen include attentional difficulties, fine motor tremors, visual sequencing problems, and depressive affect. One of the challenges for the 1990s will be rapidly to identify those infants who are at high risk of central nervous system disease progression, and to institute effective treatments that can halt the devastating effects of HIV on the developing brain. In addition to early identification of the high-risk infants, neuropsychologic, neuroimaging and laboratory measures need to be identified that will allow effective monitoring of responses to therapy.
M G Fowler
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992). Supplement     Volume:  400     ISSN:  0803-5326     ISO Abbreviation:  Acta Paediatr Suppl     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2008-05-12    
Medline Journal Info:
Nlm Unique ID:  9315043     Medline TA:  Acta Paediatr Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM; X    
Vaccine Trials and Epidemiology Branch, NIAID, NIH, Bethesda.
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MeSH Terms
CD4 Lymphocyte Count
Central Nervous System Diseases / complications*,  diagnosis,  epidemiology,  immunology
Child, Preschool
HIV Infections / complications*,  diagnosis,  epidemiology,  immunology
Magnetic Resonance Imaging
Neuropsychological Tests
Risk Factors
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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