Document Detail

Peculiar mitral valve and papillary muscle lesions induced by vagus manipulations in rabbits. An experimental model for nonrheumatic mitral regurgitation.
MedLine Citation:
PMID:  3761568     Owner:  NLM     Status:  MEDLINE    
Peculiar lesions of mitral valves and papillary muscles developed in 50 to 80% of rabbits after clipping (N = 38), crushing (N = 15) or electrical stimulation (N = 44) of their cervical vagi. Both right and left vagus manipulations induced similar cardiac lesions. The earliest manifestation was bleeding of the mitral leaflets, which was followed by swelling and fibrosis of the papillary muscles. Ventricular arrhythmias and systolic murmurs were frequently associated with the vagus manipulations. During or just after electrical stimulation of the vagus, ventricular premature contractions (VPCs) were observed in 30 of 44 animals. Twenty-nine of these 30 animals with VPCs (96.7%) were found to have mitral valve and/or papillary muscle lesions at autopsy, whereas only 5 of 14 animals without VPCs (35.7%) had the cardiac lesions. These results indicate that the occurrence of these ventricular arrhythmias during vagus manipulations was closely related with the mitral valve and papillary muscle lesions.
K Imataka; K Yamaoki; A Seki; Y Takayama; J Fujii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  27     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-11-20     Completed Date:  1986-11-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  377-86     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / etiology
Cardiomyopathies / etiology
Disease Models, Animal*
Mitral Valve Insufficiency / etiology*
Papillary Muscles
Vagus Nerve / physiology*

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