| Pearls are novel Cajal body-like structures in the Xenopus germinal vesicle that are dependent on RNA pol III transcription. | |
| | |
MedLine Citation:
|
PMID: 23135638 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We have identified novel nuclear bodies, which we call pearls, in the giant oocyte nuclei of Xenopus laevis and Xenopus tropicalis. Pearls are attached to the lampbrush chromosomes at specific loci that are transcribed by RNA polymerase III, and they disappear after inhibition of polymerase III activity. Pearls are enriched for small Cajal body-specific RNAs (scaRNAs), which are guide RNAs that modify specific nucleotides on splicing snRNAs. Surprisingly, snRNAs themselves are not present in pearls, suggesting that pearls are not functionally equivalent to Cajal bodies in other systems, which contain both snRNAs and scaRNAs. We suggest that pearls may function in the processing of RNA polymerase III transcripts, such as tRNA, 5S rRNA, and other short non-coding RNAs. |
| | |
Authors:
|
Zehra F Nizami; Joseph G Gall |
Related Documents
:
|
6253898 - Transcriptional mapping of the ribosomal rna region of mouse l-cell mitochondrial dna. 23300428 - What is the role of motif d in the nucleotide incorporation catalyzed by the rna-depend... 6294618 - Structure and transcription of the spinach chloroplast rdna leader region. 10806248 - Mutation of arabidopsis plastid phosphoglucose isomerase affects leaf starch synthesis ... 15122878 - Poliovirus rna-dependent rna polymerase (3dpol): pre-steady-state kinetic analysis of r... 22815258 - Metabolic labeling of dna by purine analogues in vivo. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-8 |
Journal Detail:
|
Title: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology Volume: - ISSN: 1573-6849 ISO Abbreviation: Chromosome Res. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9313452 Medline TA: Chromosome Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD, 21218, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Palladium-catalyzed asymmetric Heck arylation of 2,3-dihydrofuran - effect of prolinate salts.
Next Document: Effect of minimizing tension during robotic-assisted laparoscopic radical prostatectomy on urinary f...