Document Detail

Peanuts, peanut oil, and fat free peanut flour reduced cardiovascular disease risk factors and the development of atherosclerosis in Syrian golden hamsters.
MedLine Citation:
PMID:  20546405     Owner:  NLM     Status:  MEDLINE    
Human clinical trials have demonstrated the cardiovascular protective properties of peanuts and peanut oil in decreasing total and low density lipoprotein cholesterol (LDL-C) without reducing high density lipoprotein cholesterol (HDL-C). The cardiovascular effects of the nonlipid portion of peanuts has not been evaluated even though that fraction contains arginine, flavonoids, folates, and other compounds that have been linked to cardiovascular health. The objective of this study was to evaluate the effects of fat free peanut flour (FFPF), peanuts, and peanut oil on cardiovascular disease (CVD) risk factors and the development of atherosclerosis in male Syrian golden hamsters. Each experimental diet group was fed a high fat, high cholesterol diet with various peanut components (FFPF, peanut oil, or peanuts) substituted for similar metabolic components in the control diet. Tissues were collected at week 0, 12, 18, and 24. Total plasma cholesterol (TPC), LDL-C, and HDL-C distributions were determined by high-performance gel filtration chromatography, while aortic total cholesterol (TC) and cholesteryl ester (CE) were determined by gas liquid chromatography. Peanuts, peanut oil, and FFPF diet groups had significantly (P < 0.05) lower TPC, non-HDL-C than the control group beginning at about 12 wk and continuing through the 24-wk study. HDL-C was not significantly different among the diet groups. Peanut and peanut component diets retarded an increase in TC and CE. Because CE is an indicator of the development of atherosclerosis this study demonstrated that peanuts, peanut oil, and FFPF retarded the development of atherosclerosis in animals consuming an atherosclerosis inducing diet.
Amanda M Stephens; Lisa L Dean; Jack P Davis; Jason A Osborne; Timothy H Sanders
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of food science     Volume:  75     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-15     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H116-22     Citation Subset:  IM    
Dept. of Food, Bioprocessing and Nutrition Sciences, North Carolina State Univ., Raleigh, NC 27695, USA.
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MeSH Terms
Anticholesteremic Agents / administration & dosage*
Aorta / chemistry
Arachis hypogaea* / chemistry
Atherosclerosis / blood,  chemically induced,  prevention & control*
Cardiovascular Diseases / blood,  chemically induced,  prevention & control*
Cholesterol / analysis,  blood
Cholesterol Esters / analysis
Cholesterol, HDL
Cholesterol, LDL / blood
Diet, Atherogenic
Dietary Fats / administration & dosage*
Fatty Acids / analysis
Food Handling
Plant Oils / administration & dosage*,  chemistry
Risk Factors
Seeds* / chemistry
Time Factors
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol Esters; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Fatty Acids; 0/Plant Oils; 57-88-5/Cholesterol; 8002-03-7/arachis oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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