| Peak width-mass correlation in CID MS/MS of isomeric oligosaccharides using traveling-wave ion mobility mass spectrometry. | |
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MedLine Citation:
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PMID: 19753613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isomeric oligosaccharides gamma-cyclodextrin (gamma-CD), glucosyl-betaCD (Glc1-betaCD) and maltosyl-alphaCD (Glc2-alphaCD) were analyzed by traveling-wave ion mobility (twIM) mass spectrometry (MS). Their formation of multicharged multimers differed from each other. The ion mobility-mass spectrometry was useful in the self-assembling and complex formation analyses of CD isomers. The drift times of the isomers and their product ions with the same mass were almost the same in collision-induced dissociation (CID) MS/MS. In contrast, the ion mobility peak widths were sensitive to structural differences of the isomeric product ions. The twIM peak width (ms-micros) of the product ions [M-Glc(n) + H]+ (n = 0-6) of gamma-CD correlated linearly with their masses (Da); the large and/or long chain product ions had wider peak widths, which were much wider than those from the general diffusion effect. This was a novel and useful 'trend line' to discriminate between the three isomers. Plots of [M-Glc(2-6) + H]+ of Glc1-betaCD and [M-Glc(3-6) + H]+ of Glc2-alphaCD product ions' plots were on the same trend line as gamma-CD. The plots of [M-Glc1 + H]+ of Glc1-betaCD and [M-Glc(1, 2) + H]+ of Glc2-alphaCD strayed from the gamma-CD line; their peak widths were narrower than those of gamma-CD. These results indicated that product ions from the chemical species of Glc1-beta CD and Glc2-alphaCD retained their CD structure. Analyses of the IM peak widths enable us to elucidate the structures of the product ions. |
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Authors:
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Tohru Yamagaki; Akihiro Sato |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of mass spectrometry : JMS Volume: 44 ISSN: 1096-9888 ISO Abbreviation: J Mass Spectrom Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-19 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504818 Medline TA: J Mass Spectrom Country: England |
Other Details:
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Languages: eng Pagination: 1509-17 Citation Subset: IM |
Copyright Information:
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Copyright 2009 John Wiley & Sons, Ltd. |
Affiliation:
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SUNTORY Institute for Bioorganic Research, 1-1-1 Wakayamadai, Shimamoto, Mishima, Osaka 618-8503, Japan. yamagaki@sunbor.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cyclodextrins
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chemistry Isomerism Molecular Structure Oligosaccharides / chemistry* Spectrometry, Mass, Electrospray Ionization / methods* Tandem Mass Spectrometry |
| Chemical | |
Reg. No./Substance:
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0/Cyclodextrins; 0/Oligosaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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