Document Detail


Peak-to-peak amplitude in neonatal brain monitoring of premature infants.
MedLine Citation:
PMID:  22608473     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To assess the strength of association between alternative measures of electroencephalographic (EEG) signal peak-to-peak amplitude (ppA) and postmenstrual age (PMA) among a cohort of extremely premature infants. METHODS: 177 Two-channel EEG recordings 3-6h long were collected from 26 infants born before 29weeks of gestation. The raw EEG was converted into four different continuous measures of ppA: amplitude-integrated EEG (aEEG), range-EEG (rEEG), Gotman and Gloor's half-wave decomposition (HWD), and root of mean squares (RMS). For each ppA-measure EEG indices including mean, median, and 5% margins; indices of spread (width, standard deviation, coefficient of variation), and asymmetry were calculated for each 1min epoch. The medians of each index for the entire recording were tested for association with PMA using linear mixed models. RESULTS: The log-transformed values of aEEG and rEEG indices of spread were highly associated with PMA (fixed effects R(β)(2)=0.84-0.89). CONCLUSIONS: Indices of spread by aEEG or rEEG can be used as indicators of neonatal brain maturation. However, rEEG produces the absolute values that most closely approximate the raw EEG amplitudes. SIGNIFICANCE: The indices of spread and rEEG as a measure of ppA provide a basis for improvements in neonatal EEG monitoring.
Authors:
Deirdre O'Reilly; Michael A Navakatikyan; Marcia Filip; Deirdre Greene; Linda J Van Marter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-16
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  -     ISSN:  1872-8952     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Children's Hospital Boston, Newborn Medicine, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
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