Document Detail

Peak negative myocardial velocity gradient and wall-thickening velocity during early diastole are noninvasive parameters of left ventricular diastolic function in patients with Duchenne's progressive muscular dystrophy.
MedLine Citation:
PMID:  15044864     Owner:  NLM     Status:  MEDLINE    
Myocardial velocity gradient and wall-thickening velocity were measured in the interventricular septum and left ventricular posterior wall (LVPW) by color-coded M-mode Doppler tissue echocardiography in patients with Duchenne's progressive muscular dystrophy (DMD) with a normal shortening fraction (n = 14) and age-matched control subjects (n = 40). In the LVPW, peak myocardial velocity gradients during systole and early diastole were significantly lower for patients with DMD than in control subjects (P <.0005, and P <.0001, respectively). Peak myocardial wall-thickening velocities of the LVPW during systole and early diastole were also lower for patients with DMD (P <.0005 and P <.0001, respectively). Mitral peak atrial to early filling velocity ratio was not significantly different between the 2 groups. The cut-off values of peak myocardial velocity gradients and wall-thickening velocities of the LVPW during early diastole for differentiation between patients with DMD and control subjects were -5.8/s and -6.0 cm/s, respectively (sensitivity/specificity: 93%/93% and 93%/85%, respectively). In conclusion, wall thinning during early diastole is frequently abnormal in patients with DMD, even when conventional echocardiographic findings are normal.
Kazuhiro Mori; Takuji Edagawa; Miki Inoue; Masaki Nii; Ryuji Nakagawa; Yuka Takehara; Yasuhiro Kuroda; Katsunori Tatara
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  17     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2004-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  322-9     Citation Subset:  IM    
Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima-city, Japan.
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MeSH Terms
Blood Flow Velocity / physiology*
Coronary Circulation / physiology
Echocardiography, Doppler, Pulsed
Heart Rate / physiology
Heart Septum / physiopathology,  ultrasonography
Heart Ventricles / physiopathology,  ultrasonography
Muscular Dystrophy, Duchenne / epidemiology,  physiopathology*,  ultrasonography
Myocardial Contraction / physiology*
Myocardium / pathology*
Observer Variation
Sensitivity and Specificity
Time Factors
Ventricular Function, Left / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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