Document Detail


Peak power output to left ventricular mass: an index to predict ventricular pumping performance and morbidity in advanced heart failure.
MedLine Citation:
PMID:  20889309     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Similar to power-to-weight ratio and weight-to-power ratio, which are measurements of the actual performance of any engine, the ratios of peak power output to left ventricular (LV) mass (peak power/mass) and of peak LV mass to power output (peak mass/power) are indices of LV performance potentially useful in heart failure (HF). This Doppler echocardiographic study was designed to evaluate peak power/mass and peak mass/power in patients with advanced HF compared with healthy subjects and to assess their prognostic value.
METHODS: Power output was measured at rest and at peak exercise in 75 subjects, 60 patients with advanced HF (LV ejection fraction ≤ 35%) and 15 controls. Peak LV power output (W) was calculated as the maximal product of (133 × 10⁻⁶) × stroke volume (mL) × mean arterial pressure (mm Hg) × heart rate (beats/min). LV mass was assessed using a standard M-mode echocardiographic method.
RESULTS: Peak power/mass was 1.84 ± 0.46 W/100 g and 0.76 ± 0.31 W/100 g, and peak mass/power was 32 ± 10 g/m²/W and 84 ± 38 g/m²/W in controls and in patients with HF, respectively (both P values < .0001). Peak power/mass was a powerful predictor of outcome on multivariate logistic regression analysis (hazard ratio, 0.907; P = .009). On receiver operating characteristic curve analysis, the areas under the curve for HF-related events were greater for peak power/mass (P = .002) and peak mass/power (P = .011) with respect to resting ejection fraction. Comparisons of Cox models showed that peak power/mass added prognostic value to a model that included age, New York Heart Association class, etiology, ejection fraction, and diastolic dysfunction (P < .0001).
CONCLUSION: Peak power/mass is useful to discriminate and risk stratify patients with advanced HF with additional power with respect to ejection fraction.
Authors:
Frank Lloyd Dini; Donato Mele; Umberto Conti; Piercarlo Ballo; Rodolfo Citro; Francesca Menichetti; Mario Marzilli
Related Documents :
10873609 - Cardiac calcineurin during transition from hypertrophy to heart failure in rats.
4040239 - Friedreich's ataxia presenting as cardiac disease.
18307449 - Live/real time three-dimensional transthoracic echocardiographic findings in primary le...
10076919 - Cardiac and vascular remodelling: effect of antihypertensive agents.
16563789 - Ontogenetic development of the helical heart: concepts and facts.
2412429 - Effect of diuretic therapy on ventricular arrhythmias in hypertensive patients with or ...
22528059 - Left ventricular myocardium segmentation on delayed phase of multi-detector row compute...
20575469 - Utility of placental growth factor for prediction of 30-day adverse event in emergency ...
20827179 - Evolving focus on diastolic dysfunction in patients with coronary artery disease.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  23     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1259-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
Affiliation:
Cardiac, Thoracic and Vascular Department, University of Pisa, Pisa, Italy. f.dini@ao-pisa.toscana.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Congenital anomalies of inferior vena cava in young patients with iliac deep venous thrombosis.
Next Document:  Automatic point correspondence using an artificial immune system optimization technique for medical ...