Document Detail


Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes.
MedLine Citation:
PMID:  22059375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions. These results provide a new retrosynthetic disconnection for the construction of enantioenriched cis-substituted cyclopropanecarboxylic acids.
Authors:
Masayuki Wasa; Keary M Engle; David W Lin; Eun Jeong Yoo; Jin-Quan Yu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-11-21
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  133     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-07     Completed Date:  2012-04-06     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19598-601     Citation Subset:  IM    
Copyright Information:
© 2011 American Chemical Society
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry
Catalysis
Cyclopropanes / chemical synthesis,  chemistry*
Ligands
Palladium / chemistry*
Grant Support
ID/Acronym/Agency:
1 R01 GM084019-02/GM/NIGMS NIH HHS; R01 GM084019/GM/NIGMS NIH HHS; R01 GM084019-02/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Cyclopropanes; 0/Ligands; 008803351S/cyclopropanecarboxylic acid; 5TWQ1V240M/Palladium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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