Document Detail


Pd(0)-catalyzed oxy- and aminoalkynylation of olefins for the synthesis of tetrahydrofurans and pyrrolidines.
MedLine Citation:
PMID:  22070183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first Pd(0)-catalyzed intramolecular oxy- and aminoalkynylation of nonactivated olefins is reported. The reaction gives access to important tetrahydrofuran and pyrrolidine heterocycles with high diastereoselectivity. The unique synthetic potential of acetylenes is further exploited to access key building blocks for the synthesis of bioactive natural products.
Authors:
Stefano Nicolai; Jérôme Waser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-09
Journal Detail:
Title:  Organic letters     Volume:  13     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-02-08     Revised Date:  2012-09-05    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6324-7     Citation Subset:  IM    
Affiliation:
Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Alkenes / chemistry*
Alkynes / chemistry*
Catalysis
Combinatorial Chemistry Techniques
Furans / chemical synthesis*,  chemistry
Molecular Structure
Palladium / chemistry*
Pyrrolidines / chemical synthesis*,  chemistry
Chemical
Reg. No./Substance:
0/Alkenes; 0/Alkynes; 0/Furans; 0/Pyrrolidines; 7440-05-3/Palladium
Comments/Corrections
Erratum In:
Org Lett. 2012 Jul 6;14(13):3563

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