| PD-1 and BTLA and CD8(+) T-cell "exhaustion" in cancer: "Exercising" an alternative viewpoint. | |
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MedLine Citation:
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PMID: 22934265 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The elevated expression of PD-1, BTLA, and other co-inhibitory molecules on T cells from cancer patients has become an accepted signature for a state called T-cell "exhaustion" that has emerged almost as dogma in the field. However, here we propose that in some cases this "exhausted" T-cell phenotype may instead be an indicator of T cells that are in a more heightened state of T-cell activation more susceptible to negative regulation rather than being "exhausted." This alternative interpretation fits in line with the view that CD8(+) T-cell activation in cancer results from a continuum of signals regulating their differentiation towards potent effector cells. |
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Authors:
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Cara Haymaker; Richard Wu; Chantale Bernatchez; Laszlo Radvanyi |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Oncoimmunology Volume: 1 ISSN: 2162-402X ISO Abbreviation: Oncoimmunology Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101570526 Medline TA: Oncoimmunology Country: - |
Other Details:
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Languages: ENG Pagination: 735-738 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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