Document Detail


PD-1 and BTLA and CD8(+) T-cell "exhaustion" in cancer: "Exercising" an alternative viewpoint.
MedLine Citation:
PMID:  22934265     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The elevated expression of PD-1, BTLA, and other co-inhibitory molecules on T cells from cancer patients has become an accepted signature for a state called T-cell "exhaustion" that has emerged almost as dogma in the field. However, here we propose that in some cases this "exhausted" T-cell phenotype may instead be an indicator of T cells that are in a more heightened state of T-cell activation more susceptible to negative regulation rather than being "exhausted." This alternative interpretation fits in line with the view that CD8(+) T-cell activation in cancer results from a continuum of signals regulating their differentiation towards potent effector cells.
Authors:
Cara Haymaker; Richard Wu; Chantale Bernatchez; Laszlo Radvanyi
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Oncoimmunology     Volume:  1     ISSN:  2162-402X     ISO Abbreviation:  Oncoimmunology     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101570526     Medline TA:  Oncoimmunology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  735-738     Citation Subset:  -    
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