| Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. | |
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MedLine Citation:
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PMID: 21945644 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the efficacy of pazopanib eye drops in the streptozotocin induced diabetic retinopathy rat model. METHODS: A 0.5% w/v pazopanib suspension was prepared in phosphate buffered saline (PBS, pH 7.4) in the presence of 0.5% w/v sodium carboxymethyl cellulose. Brown Norway rats were divided into three groups (n=4) - (1) healthy, (2) diabetic, and (3) diabetic with treatment. The drug suspension was administered twice daily as eye drops to group 3 for 30days. Efficacy parameters including the number of adherent leukocytes in the retinal vasculature (leukostasis), blood-retinal FITC-dextran leakage, and vitreous-to-plasma protein ratio were measured. RESULTS: Pazopanib suspension in the form of eye drops significantly reduced leukostasis (32%), FITC-dextran leakage (39%), and the vitreous-to-plasma protein ratio (64%) in diabetic animals compared to untreated diabetic group. CONCLUSION: Pazopanib eye drops can alleviate retinal complications of diabetic retinopathy. |
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Authors:
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Ashish Thakur; Robert I Scheinman; Vidhya R Rao; Uday B Kompella |
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Publication Detail:
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Type: - Date: 2011-9-16 |
Journal Detail:
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Title: Microvascular research Volume: - ISSN: 1095-9319 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Nanomedicine and Drug Delivery Laboratory, Department of Pharmaceutical Sciences, Aurora, CO 80045, USA; Department of Pharmaceutical Sciences, 985840 Nebraska Medical Center, Omaha, NE 68198-5840, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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