Document Detail


Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5.
MedLine Citation:
PMID:  16510508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuronal migration is a prerequisite event for the establishment of highly ordered neuronal circuits in the developing brain. Here, we report Pax6-dependent alignment of the olfactory cortex neurons in the developing telencephalon. These neurons were generated in the dorsal part of telencephalon, migrated ventrally and stopped at the pallium-subpallium boundary (PSB). In Pax6 mutant rat embryos, however, these neurons invaded the ventral part of the telencephalon by crossing the PSB. Ephrin A5, one of the ligands for EphA receptors, was specifically expressed in the ventral part of the telencephalon, and its expression level was markedly reduced in the Pax6 mutant. Gain- and loss-of-function studies of ephrin A5 indicated that ephrin A5 plays an important role in the alignment of olfactory cortex neurons at the PSB. Our results suggest that Pax6-regulated ephrin A5 acts as a repulsive molecule for olfactory cortex neurons in the developing telencephalon.
Authors:
Tadashi Nomura; Johan Holmberg; Jonas Frisen; Noriko Osumi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-01
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  133     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-10     Completed Date:  2006-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  1335-45     Citation Subset:  IM    
Affiliation:
Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Seiryo-machi, 980-8575, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Cerebral Cortex
Down-Regulation
Ephrin-A5 / metabolism*
Eye Proteins / genetics,  metabolism*
Female
Gene Expression Regulation, Developmental
Heterozygote
Homeodomain Proteins / genetics,  metabolism*
Immunohistochemistry
In Situ Hybridization
Models, Biological
Mutation
Neurons / cytology*,  metabolism*
Olfactory Bulb / cytology*,  embryology,  metabolism*
Paired Box Transcription Factors / genetics,  metabolism*
Pregnancy
Rats
Rats, Sprague-Dawley
Repressor Proteins / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Ephrin-A5; 0/Eye Proteins; 0/Homeodomain Proteins; 0/PAX6 protein; 0/Paired Box Transcription Factors; 0/Repressor Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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