Document Detail


Patterns of wheel running are related to Fos expression in neuropeptide-Y-containing neurons in the intergeniculate leaflet of Arvicanthis niloticus.
MedLine Citation:
PMID:  11302558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A variety of nonphotic influences on circadian rhythms have been documented in mammals. In hamsters, one such influence, running in a novel wheel, is mediated in part by the pathway extending from neuropeptide-Y (NPY)-containing cells within the intergeniculate leaflet (IGL) of the thalamus to the hypothalamic suprachiasmatic nucleus (SCN). Arvicanthis niloticus is a species in which all individuals are diurnal with respect to general activity and body temperature when they are housed without a running wheel, but access to a running wheel induces a subset of individuals to become nocturnal. In the first study, the authors evaluated the possibility that nocturnal and diurnal patterns of wheel running in Arvicanthis are correlated with differences in IGL function. Adult male Arvicanthis housed in a 12:12 light-dark (LD) cycle were monitored in wheels, classified as nocturnal or diurnal, and then perfused either 4 h after lights-on or 4 h after lights-off. Sections through the intergeniculate leaflet were processed for immunohistochemical labeling of Fos and NPY. The percentage of NPY cells that expressed Fos was significantly influenced by an interaction between time of day and phenotype such that it rose from night to day in diurnal animals, and from day to night in nocturnal animals. In the second experiment, the authors established that running in a wheel actually induces Fos in the IGL of Arvicanthis. Specifically, the proportion of NPY cells expressing Fos was increased by access to wheels in nocturnal animals at night and in diurnal animals during the day. In the third experiment, the authors established that lesions of the IGL eliminate NPY fibers within the SCN, suggesting that these IGL cells project to the SCN in this species as has been established in other rodents. Together, these data demonstrate a clear difference in NPY cell function in nocturnal and diurnal Arvicanthis that appears to be caused, at least in part, by the differences in their wheel-running patterns, and that NPY cells within the IGL project to the SCN in Arvicanthis.
Authors:
L Smale; T Mcelhinny; J Nixon; B Gubik; S Rose
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biological rhythms     Volume:  16     ISSN:  0748-7304     ISO Abbreviation:  J. Biol. Rhythms     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-13     Completed Date:  2001-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8700115     Medline TA:  J Biol Rhythms     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-72     Citation Subset:  IM    
Affiliation:
Department of Psychology, Michigan State University, East Lansing 48824, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Rhythm / physiology
Geniculate Bodies / cytology,  metabolism*
Male
Motor Activity / physiology*
Muridae / physiology*
Nerve Fibers / metabolism
Neurons / metabolism*
Neuropeptide Y / metabolism*
Proto-Oncogene Proteins c-fos / biosynthesis*
Grant Support
ID/Acronym/Agency:
R01 MH53433/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 0/Proto-Oncogene Proteins c-fos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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