Document Detail

Patterns of use of FDG-PET for the initial staging of grade 1-2 follicular lymphoma and its impact on initial treatment strategy in the National Comprehensive Cancer Network non-Hodgkin lymphoma outcomes database.
MedLine Citation:
PMID:  23343180     Owner:  NLM     Status:  Publisher    
Abstract We describe the patterns of use of 18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for the initial staging of patients with newly diagnosed grade 1-2 follicular lymphoma (FL) and its potential impact on treatment. Data were obtained from the National Comprehensive Cancer Network non-Hodgkin Lymphoma Outcomes Database. Patients who presented between January 1, 2001 and September 30, 2009 with newly diagnosed grade 1-2 FL, with at least 6 months of follow-up were included. We identified 953 eligible patients and 532 (56%) underwent FDG-PET as part of initial staging. Among patients who underwent FDG-PET for initial staging, 438 (82%) received early treatment compared to 259 (61.5%) of those staged without FDG-PET (p<0.0001). Of all stage 1 FL (n=100), 47% were treated with radiotherapy (RT) alone and the choice of initial treatment strategy for stage 1 FL did not vary significantly by use of FDG-PET (p=0.22). The use of FDG-PET for staging of FL is widespread and is associated with a greater proportion of patients receiving early therapy. Given the widespread use and high cost of FDG-PET, its clinical utility in stage 1 FL should be further evaluated.
Karim E Abou-Nassar; Ann Vanderplas; Jonathan W Friedberg; Gregory A Abel; Joyce Niland; Maria A Rodriguez; Myron S Czuczman; Michael Millenson; Allison Crosby; Leo I Gordon; Andrew D Zelenetz; Mark Kaminski; Ann S Lacasce
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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