Document Detail


Patterns of temperature adaptation in proteins from Methanococcus and Bacillus.
MedLine Citation:
PMID:  10605119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has long been known that amino acid substitutions in proteins of organisms living at moderate and high temperatures (mesophiles and thermophiles, respectively) are not all symmetrical; for example, more aligned sites have lysine in mesophiles and arginine in thermophiles than have the opposite pattern. This is generally taken to indicate that certain amino acids are favored over others by selection at different temperatures. Previous comparisons of protein sequences from mesophiles and thermophiles have used relatively small numbers of sequences from a diverse array of species, meaning that only the most common amino acid substitutions could be examined and any taxon-specific patterns would be obscured. Here, we compare a large number of proteins between mesophiles and thermophiles in the archaeal genus Methanococcus and the bacterial genus Bacillus. Each genus exhibits dramatically asymmetrical substitution patterns for many pairs of amino acids. There are several pairs of amino acids for which one amino acid is favored in thermophilic Bacillus and the other is favored in thermophilic Methanococcus; this appears to result from the higher G + C content of the DNA of thermophilic Bacillus, a complication not seen in Methanococcus.
Authors:
J H McDonald; A M Grasso; L K Rejto
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Molecular biology and evolution     Volume:  16     ISSN:  0737-4038     ISO Abbreviation:  Mol. Biol. Evol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-31     Completed Date:  2000-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501455     Medline TA:  Mol Biol Evol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1785-90     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, University of Delaware, Newwark 19716, USA. mcdonald@udel.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Biological / genetics*
Amino Acid Sequence
Bacillus / genetics*
Bacterial Proteins / chemistry,  genetics
Heating
Methanococcus / genetics*
Molecular Sequence Data
Proteins / chemistry,  genetics*
Sequence Alignment
Sequence Analysis, Protein
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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