Document Detail

Patterns of symptom reporting during pregnancy comparing opioid maintained and control women.
MedLine Citation:
PMID:  23135165     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : To characterize the range of symptoms experienced by pregnant methadone-maintained (MM) and buprenorphine-maintained (BM) women to determine whether these differ from those experienced by a control group of nonopioid exposed pregnant women. Opioid-maintained (OM) patients report high rates of symptoms related to direct opioid effects and withdrawal. Pregnancy is associated with a range of symptoms, some overlapping with opioid effects and withdrawal.
METHODS: : Prospective, nonrandomized, open-label comparison study undertaken in a large teaching maternity hospital in South Australia. Pregnant BM (n = 25), MM (n = 25) and nonopioid exposed controls (n = 25) were recruited and matched for age, parity, gravidity, alcohol consumption, and smoking status. Symptom report patterns, maternal withdrawal, and additional substance use were assessed.
RESULTS: : MM women reported 10 and BM women reported 2 symptoms throughout pregnancy at rates greater than controls. Methadone-maintained women reported significantly (P < 0.05) more symptoms than BM women compared to controls throughout pregnancy. Methadone-maintained women reported 8 and BM women reported 3 symptoms in the third trimester at rates greater than controls. Methadone-maintained women reported greater opioid withdrawal than controls; this did not occur in BM women. Additional substance use was comparable between BM and MM women but greater than controls.
CONCLUSIONS: : Patterns of symptom reports may have clinical implications for maternal and fetal health during pregnancy for OM women including optimization of opioid dosing regimens, education regarding maternal nutritional intake and preventing postnatal depression, thereby ensuring maternal health and fetal development during pregnancy and enhancing mother-infant bonding and healthy child development postnatally.
Andrea L Gordon; Olga V Lopatko; Helen Stacey; Vicki Pearson; Anna Woods; Ann Fisk; Jason M White
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of addiction medicine     Volume:  6     ISSN:  1932-0620     ISO Abbreviation:  J Addict Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101306759     Medline TA:  J Addict Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-64     Citation Subset:  IM    
From School of Nursing and Midwifery and School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, Division of Health Sciences, University of South Australia (ALG, JMW); Discipline of Pharmacology, University of Adelaide, Adelaide, Australia (ALG, OVL, JMW); Women's and Children's Hospital, Adelaide, Australia (HS); and Drug and Alcohol Services South Australia, Australia (VP, AF, AW).
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