| Patterns of stress in schizophrenia. | |
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MedLine Citation:
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PMID: 18514323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although it is widely recognized that stress plays a key role in the pathophysiology of schizophrenia, little is known regarding the particular types of stress patients experience. Less is known about the interplay among stressful events, personality mediators, and emotional responses. In this study, we investigated 10 stress dimensions in 29 patients with schizophrenia and 36 healthy volunteers using the Derogatis Stress Profile (DSP), and the relationship between these dimensions and symptoms in patients. Overall, patients had an approximate 0.75 standard deviation increase in stress compared with healthy volunteers. Significant increases in stress among patients compared with healthy volunteers were observed specifically in areas related to domestic environment, driven behavior, and depression, but not in health, attitude posture, time pressure, relaxation potential, role definition, hostility, or anxiety. More DSP-rated depression among patients correlated significantly with greater negative symptom severity. Patients with a shorter duration of antipsychotic drug exposure had significantly greater hostility than did patients with a longer duration of exposure, but did not differ in any other dimension. Continued investigation of domestic environmental stressors, driven behavior, and depression may be useful in identifying high-risk groups, and understanding symptom exacerbation and precipitants of relapse in patients already diagnosed with schizophrenia. |
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Authors:
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Julia D Betensky; Delbert G Robinson; Handan Gunduz-Bruce; Serge Sevy; Todd Lencz; John M Kane; Anil K Malhotra; Rachel Miller; Joanne McCormack; Robert M Bilder; Philip R Szeszko |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-06-02 |
Journal Detail:
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Title: Psychiatry research Volume: 160 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-16 Completed Date: 2008-10-08 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 38-46 Citation Subset: IM |
Affiliation:
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Department of Psychiatry Research, The Zucker Hillside Hospital, North-Shore-Long Island Jewish Health System, Glen Oaks, NY 11004, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Antipsychotic Agents / therapeutic use Comorbidity Control Groups Depressive Disorder / diagnosis, epidemiology, psychology Family / psychology Female Hostility Humans Male Personality Inventory / statistics & numerical data Psychiatric Status Rating Scales / statistics & numerical data Psychometrics Recurrence Risk Factors Schizophrenia / diagnosis*, drug therapy, epidemiology Schizophrenic Psychology Severity of Illness Index Social Environment Stress, Psychological / diagnosis*, epidemiology, psychology |
| Grant Support | |
ID/Acronym/Agency:
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DA015541/DA/NIDA NIH HHS; K01 MH001990-05/MH/NIMH NIH HHS; K23 DA015541-04/DA/NIDA NIH HHS; M01 RR018535/RR/NCRR NIH HHS; M01 RR018535-06/RR/NCRR NIH HHS; MH01990/MH/NIMH NIH HHS; MH60004/MH/NIMH NIH HHS; MH60374/MH/NIMH NIH HHS; MH60575/MH/NIMH NIH HHS; P30 MH060575-05/MH/NIMH NIH HHS; R01 MH060004-08/MH/NIMH NIH HHS; R01 MH060374-05/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents |
| Comments/Corrections | |
Comment In:
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Psychiatry Res. 2009 Jan 30;165(1-2):197-8; author reply 199-200
[PMID:
19058858
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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