Document Detail

Patterns of stress in schizophrenia.
MedLine Citation:
PMID:  18514323     Owner:  NLM     Status:  MEDLINE    
Although it is widely recognized that stress plays a key role in the pathophysiology of schizophrenia, little is known regarding the particular types of stress patients experience. Less is known about the interplay among stressful events, personality mediators, and emotional responses. In this study, we investigated 10 stress dimensions in 29 patients with schizophrenia and 36 healthy volunteers using the Derogatis Stress Profile (DSP), and the relationship between these dimensions and symptoms in patients. Overall, patients had an approximate 0.75 standard deviation increase in stress compared with healthy volunteers. Significant increases in stress among patients compared with healthy volunteers were observed specifically in areas related to domestic environment, driven behavior, and depression, but not in health, attitude posture, time pressure, relaxation potential, role definition, hostility, or anxiety. More DSP-rated depression among patients correlated significantly with greater negative symptom severity. Patients with a shorter duration of antipsychotic drug exposure had significantly greater hostility than did patients with a longer duration of exposure, but did not differ in any other dimension. Continued investigation of domestic environmental stressors, driven behavior, and depression may be useful in identifying high-risk groups, and understanding symptom exacerbation and precipitants of relapse in patients already diagnosed with schizophrenia.
Julia D Betensky; Delbert G Robinson; Handan Gunduz-Bruce; Serge Sevy; Todd Lencz; John M Kane; Anil K Malhotra; Rachel Miller; Joanne McCormack; Robert M Bilder; Philip R Szeszko
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-06-02
Journal Detail:
Title:  Psychiatry research     Volume:  160     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-10-08     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  38-46     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Antipsychotic Agents / therapeutic use
Control Groups
Depressive Disorder / diagnosis,  epidemiology,  psychology
Family / psychology
Personality Inventory / statistics & numerical data
Psychiatric Status Rating Scales / statistics & numerical data
Risk Factors
Schizophrenia / diagnosis*,  drug therapy,  epidemiology
Schizophrenic Psychology
Severity of Illness Index
Social Environment
Stress, Psychological / diagnosis*,  epidemiology,  psychology
Grant Support
DA015541/DA/NIDA NIH HHS; K01 MH001990/MH/NIMH NIH HHS; K01 MH001990-05/MH/NIMH NIH HHS; K23 DA015541-04/DA/NIDA NIH HHS; M01 RR018535/RR/NCRR NIH HHS; M01 RR018535/RR/NCRR NIH HHS; M01 RR018535-06/RR/NCRR NIH HHS; MH01990/MH/NIMH NIH HHS; MH60004/MH/NIMH NIH HHS; MH60374/MH/NIMH NIH HHS; MH60575/MH/NIMH NIH HHS; P30 MH060575-05/MH/NIMH NIH HHS; R01 MH060004/MH/NIMH NIH HHS; R01 MH060004-08/MH/NIMH NIH HHS; R01 MH060374/MH/NIMH NIH HHS; R01 MH060374-05/MH/NIMH NIH HHS
Reg. No./Substance:
0/Antipsychotic Agents
Comment In:
Psychiatry Res. 2009 Jan 30;165(1-2):197-8; author reply 199-200   [PMID:  19058858 ]

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